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Any of a group of neurologically active compounds, including glutamate and aspartame, that in high concentrations have detrimental excitatory effects on the central nervous system and may cause injury to nerve cells.

[excit(atory) + toxin.]

ex·ci′to·tox′ic (ĭk-sī′tə-tŏk′sĭk) adj.
References in periodicals archive ?
Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity. Cell 2005;120:275-85.
Neuroimmune signaling and glutamate excitotoxicity are linked to alcoholic neurodegeneration.
Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity. Brain 2009; 132: 3152-3164.
These include glutamatergic excitotoxicity,21 hyperlipidemia, hypertension, smoking, (22) immunogenic demyelination of white matter, (23) mitochondrial dysfunction, (24) endothelial dysfunction, (25,26) attack-related oligemia and focal hypoperfusion, (27) and vasoactive drugs like triptans or ergots.
Further its inhibitory actions in brain prevents excitotoxicity and protects against neuronal damage.
Furthermore, hippocampal GLU in CAPs-exposed males was positively correlated with hippocampal IL-1[beta]/IL-6, likely indicating a mechanistic link between excitotoxicity and neuro i nflammatory responses.
Common targets for neuroprotection include increased levels in oxidative stress, mitochondrial dysfunction, excitotoxicity, inflammatory processes, and protein aggregation.
Ischemia can induce excessive NMDA stimulation leading to excitotoxicity, which suggests that agents that block stimulation of NMDA receptors might be protective against further damage vascular dementia (VaD) 10.
Glutamate excitotoxicity and oxidative stress have been suggested as one of the important pathophysiological mechanisms in glaucomatous neurodegeneration [74, 75].
Our results suggest that HEK-CM protects hippocampal neurons against excitotoxicity by stimulating the host's endogenous cell survival mechanisms.
Excitotoxicity and disrupted energy metabolism act in a synergistic manner, leading to nerve cell death in neurodegenerative disorders [23].