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Any of a group of neurologically active compounds, including glutamate and aspartame, that in high concentrations have detrimental excitatory effects on the central nervous system and may cause injury to nerve cells.

[excit(atory) + toxin.]

ex·ci′to·tox′ic (ĭk-sī′tə-tŏk′sĭk) adj.
References in periodicals archive ?
It also can act as an excitotoxin, over-stimulating and damaging or killing nerve cells.
Along with these prevalent dietary factors, stress and excitotoxin exposure, which raise cortisol and other stress hormones, influence our physiological requirement for a variety of water-soluble nutrients (e.
Monosodium glutamate (MSG) is another toxic chemical and an excitotoxin, as it is able to "overstimulate cells to death.
Pyrethrins act as an axionic excitotoxin on bed bugs, which effectively paralyzes them by messing with the sodium channels that regulate their nerve cells.
Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure.
It serves as an excitatory neurotransmitter in the brain and is an excitotoxin.
Double dissociations of the effects of amygdala and insular cortex lesions on conditioned taste aversion, passive avoidance, and neophobia in the rat using the excitotoxin ibotenic acid.
Behavioral disinhibition following basal forebrain excitotoxin lesions: Alcohol consumption, defensive aggression, impulsivity and serotonin levels.
Domoic Acid (DA), a potent excitotoxin produces hippocampal damage and functional lesions as seen in temporal lobe epilepsy.
But aspartame acts like an excitotoxin, and excitotoxins are dangerous.
MSG is an excitotoxin that works by overstimulating its nerve target.