It also can act as an excitotoxin
, over-stimulating and damaging or killing nerve cells.
Evidence in support of this concept includes the demonstration that functional ablation of primary sensory neurons by systemic administration of high doses of the TRPV1 excitotoxin
, capsaicin, for 3 consecutive days in adult rats strongly inhibited the inflammatory effects of toxin A .
ACMSD can prevent the accumulation of the neuronal excitotoxin
quinolinate, which has been implicated in the pathogenesis of several neurodegenerative disorders (https: //www.ncbi.nlm.nih.gov/gene/130013, updated 19-Jan-2017).
3-HAA is further metabolized to quinolinic acid (QA), the excitotoxin
, which is a potent convulsant and excitant .
Along with these prevalent dietary factors, stress and excitotoxin
exposure, which raise cortisol and other stress hormones, influence our physiological requirement for a variety of water-soluble nutrients (e.g.
Monosodium glutamate (MSG) is another toxic chemical and an excitotoxin
, as it is able to "overstimulate cells to death." In studies, MSG caused muscle tightness, fatigue, numbness, allergies, headaches, and obesity among others.
(Pyrethrins act as an axionic excitotoxin
on bed bugs, which effectively paralyzes them by messing with the sodium channels that regulate their nerve cells.) Craig shoos Michael out of his suite for a minimum of four hours to ensure he isn't affected by the application of Cyfluthrin, then pulls on his purple respirator and closes the door to begin spraying every nook and cranny of the room.
Kainic acid (KA; Tocris, Bristol, UK) was used as an excitotoxin
in the present study.
Gahring, "Inflammatory cytokines IL-1a, IL-1/3, IL-6, and TNF-[alpha] impart neuroprotection to an excitotoxin
through distinct pathways," Journal of Immunology, vol.
Furthermore, incubating rat brain tissue homogenates in the presence of QA (a well-known excitotoxin
that induces oxidative stress and damage) caused a significant (P < 0.05) increase in the MDA production in the brain as shown in Figure 3(c).
It serves as an excitatory neurotransmitter in the brain and is an excitotoxin
. As a neurotransmitter, aspartic acid may provide resistance to fatigue, and thus, leads to endurance, although the evidence to support this idea is not strong (Zeigler et al., 1996).