Unlike other glucagon-like peptide-1 (GLP-1) receptor agonists, Bydureon BCise has a unique, continuous-release microsphere delivery system designed to provide consistent therapeutic levels of the active ingredient, exenatide
, to help patients reach and maintain steady state.
Existing treatments merely ameliorate symptoms of Parkinson's, such as tremors and stiffness, but the study published in The Lancet suggests that the drug exenatide
targets its underlying cause.
PATIENTS WITH TYPE 2 diabetes who took once-daily exenatide
did not appear to have an increase in their overall cardiovascular risk, compared with those who took placebo, a large randomized trial demonstrated.
Synthetic exendin-4 was approved as exenatide
for twice-daily injection by the US Food and Drug Administration (FDA) in 2005, becoming the first GLP-1 receptor agonist (GLP-IRA).
Keywords: Dulaglutide, insulin degludec, degludec aspart (I Deg Asp), exenatide
QW, liraglutide (I Deg Lira), lixisenatide, liraglutide, lixisenatide glargine (Lixi Lan), U300 glargine.
The trial achieved its primary endpoint with the combination of exenatide
and dapagliflozin significantly reducing HbA1c from baseline compared with exenatide
or dapagliflozin alone (1.
Methods: Isolated neonatal rat cardiomyocytes were divided into three groups: Control group, with cells cultured in normal conditions without intervention; TNF-a group, with cells incubated with TNF-a (40 ng/ml) for 6, 12, or 24 h without pretreatment with exenatide
; and exenatide
group, with cells pretreated with exenatide
(100 nmol/L) 30 mins before TNF-a (40 ng/ml) stimulation.
is a glucagon-like peptide-1 receptor agonist that is commonly used in the treatment of type II diabetes mellitus for its effects on the incretin system.
CHICAGO -- Starting patients with newly diagnosed type 2 diabetes on the combination of metformin, pioglitazone, and exenatide
proved superior to standard guideline-recommended sequential add-on therapy with metformin, a sulfonylurea, and basal insulin in a 2-year randomized trial.
had issued warnings about pancreatitis associated with exenatide
(Byetta[R] and Bydureon[R]) and sitagliptin (Januvia[R], Janumet[R]).
The drug, called exenatide
, can be given to people with Type 2 diabetes who cannot get their condition under control with currently available pills, the Daily Express reported.
Amylin is excited to assume full responsibility for developing and commercializing exenatide