exonuclease

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ex·o·nu·cle·ase

 (ĕk′sō-no͞o′klē-ās′, -āz′, -nyo͞o′-)
n.
Any of a group of enzymes that catalyze the hydrolysis of single nucleotides from the end of a DNA or RNA chain.

exonuclease

(ˌɛksəʊˈnjuːklɪˌeɪz)
n
(Biochemistry) an enzyme that is capable of detaching the terminal nucleotide from a nucleic acid chain. Compare endonuclease
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.exonuclease - a nuclease that releases one nucleotide at a time (serially) beginning at one of a nucleic acid
nuclease - general term for enzymes that catalyze the hydrolysis of nucleic acid by cleaving chains of nucleotides into smaller units
References in periodicals archive ?
For the protection of the 3' end against degradation by exonucleases and the export of mature mRNA to the cytoplasmic environment, nuclear polyadenylation is a crucial step (17).
That's fine, and to get rid of uncircularized probes we now add in single strand-specific DNA exonucleases. These "chew up" linear single-stranded DNA but leave any circular molecules intact.
Both DNA and RNA are generally linear tetrapolymers, and nuclease enzymes known as exonucleases hydrolytically cleave these types of polymers at their ends (e.g., Phosphodiesterase I), while endonuclease enzymes cleave the polymer chain at internal locations (e.g., DNase I, EcoRI).
In addition, chemically modified sgRNA may aid in editing challenging targets even in common cell lines, and can provide protection against exonucleases in prokaryotic cells.
According to previous publications, circRNAs are more stable than linear mRNA in RNA exonucleases. The increase or decrease in circRNAs expression levels in tumors compared with normal tissues may serve as a useful biomarker in tumor diagnosis and prognosis.
In addition, truncated mRNA, missing poly(A), can be subjected to the 3' to 5' degradation of cytoplasmic exonucleases [67-69].
Ma et al., "A comparison of eubacterial and archaeal structure-specific 5;- exonucleases," Journal ofBiological Chemistry, vol.
Additionally, we have modified the probes' 3,-termini by thymidine attached via a 3,-3,-phosphodiester internucleotide bond (37-"inverted" thymidine) to achieve greater stability to exonucleases [15-17].