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Related to F-actin: phalloidin, G-actin, Vinculin


A protein that forms the microfilaments of the eukaryotic cytoskeleton and plays an important role in cell movement, shape, and internal organization. In muscle cells, it functions with myosin to produce contraction.

[Latin āctus, motion; see act + -in.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Biochemistry) a protein that participates in many kinds of cell movement, including muscle contraction, during which it interacts with filaments of a second protein, myosin
[C20: from act + -in]
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˈæk tən)

a protein that functions in muscular contraction by combining with myosin. Compare actomyosin.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.actin - one of the proteins into which actomyosin can be split; can exist in either a globular or a fibrous form
actomyosin - a protein complex in muscle fibers; composed of myosin and actin; shortens when stimulated and causes muscle contractions
simple protein - a protein that yields only amino acids when hydrolyzed
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
COQ6 knockdown in podocytes was performed in vitro with small interfering RNA, and then, F-actin was determined using immunofluorescence staining.
Actin-depolymerizing factor and cofilin-1 play overlapping roles in promoting rapid F-actin depolymerization in mammalian nonmuscle cells.
Actin is a globular monomeric protein (G-actin) that spontaneously polymerizes to form filamentous-actin (F-actin), the framework of the thin filament.
SMA staining patterns for AIH-1 correlate with flamentous actin (F-actin) (7).
Rho controls cortical F-actin disassembly in addition to, but independently of, secretion in Mast cells.
Moreover, a different group identified cofilin and its regulatory kinase LIM-kinase 1 (LIMK1) as binding partners of 14-3-3[zeta] and suggested that interactions with the C-terminal region of 14-3-3[zeta] inhibit the binding of cofilin to F-actin [59].
The cell adhesion and connection behavior were investigated by fluorescent staining of F-actin (by rhodamine-phalloidin, shown as red) and nuclei (by DAPI, shown as blue), respectively.
PLS3 is important for axonogenesis, and overexpression of PLS3 levels may elevate F-actin amounts and rescue the axonal length and outgrowth defects in SMA patients [10-12].
S1: List of antibodies used in this study Target name Antibody name Host HNK1 Monoclonal anti-human CD57/HNK-1 mouse IgM p75 NGFr (ME20.4, p75) Mouse Monoclonal mouse IgG1 Nestin Monoclonal Mouse IgG1 clone #196908 mouse IgG1 Pax6 Purified anti-Pax-6 antibody rabbit GFAP Anti-GFAP antibody [2A5] mouse IgG1 F-actin Alexa Fluor[R] 568 Phalloidin -- Target name Dilution Catalog # Provider HNK1 1:200 C6680 Sigma p75 1:200 #AB-N07 Advanced Nestin 1:500 MAB1259 R&D Systems Pax6 1:200 PRB-278P Covance GFAP 1:1000 ab4648 Abcam F-actin 1:1000 A12380 Invitrogen Tab.
(1984) Direct observation of motion of single F-actin filaments in the presence of myosin.