The spreadsheet file reported herein provides centroid data, descriptive of deuterium uptake, for the Fab Fragment
of NISTmAb (PDB: 5K8A) reference material, as measured by the bottom-up hydrogen-deuterium exchange mass spectrometry (HDX-MS) method.
It is a compound consisting of the Fab fragment
of the tumor necrosis factor alpha monoclonal antibody and polyethylene glycol.
Similarly, free light-chain antibodies do not detect light chains still bound to heavy chains in the Fab fragment
A neutralizing recombinant human antibody Fab fragment
against Puumala hantavirus.
Nestor, "In vivo characterization of the novel CD44v6-targeting Fab fragment
AbD15179 for molecular imaging of squamous cell carcinoma: A dual-isotope study," EJNMMI Research, vol.
Data being presented from UCBs pipeline include Phase 3 results from the STRUCTURE study of romosozumab for osteoporosis in post-menopausal women, Phase 1b results in PsA for bimekizumab (UCB4940), an investigational monoclonal antibody specifically designed to potently and selectively inhibit the biological function of both IL-17A and IL-17F cytokines, and Phase 1 results for dapirolizumab pegol (CDP7657), an anti-CD40L pegylated Fab fragment
being evaluated for SLE.
In contrast, fusion proteins that contain the Fc portion and Fab fragment
appear to have limited ability to cross the placenta.
Via its Fab fragment
, RTX is able to link with CD20, the receptor present on the surface of the majority of B-cells.
UCB's Cimzia is a pegylated Fab fragment
of a humanized anti-TNF IgG molecule, and is indicated for the treatment of adult patients with moderate to severe RA.
Kikuchi et al., "Distribution of immunoglobulin Fab fragment
conjugated with HIV-1 REV peptide following intravenous administration in rats," Molecular Pharmaceutics, vol.
Analysis of the Characters of the Anti-P-gp Fab Fragment
Expressed in E.
Certolizumab (Cimzia) is a humanized monoclonal Fab fragment
conjugated to polyethylene glycol, giving it a lengthy plasma half-life of nearly 2 weeks.