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Related to Fas ligand: Fas protein, CD95, Fas receptor, Granzyme B


 (lī′gənd, lĭg′ənd)
An ion, molecule, or molecular group that binds to another chemical entity to form a larger complex.

[From Latin ligandus, gerundive of ligāre, to bind; see ligate.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(ˈlɪɡənd; ˈlaɪ-)
(Chemistry) chem an atom, molecule, radical, or ion forming a complex with a central atom
[C20: from Latin ligandum, gerund of ligāre to bind]
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˈlaɪ gənd, ˈlɪg ənd)

1. a molecule, as an antibody, hormone, or drug, that binds to a receptor.
2. a molecule, ion, or atom that is bonded to the central metal atom of a coordination compound.
[1945–50; < Latin ligandus, ger. of ligāre to bind, tie]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.ligand - a substance (an atom or molecule or radical or ion) that forms a complex around a central atom
substance - a particular kind or species of matter with uniform properties; "shigella is one of the most toxic substances known to man"
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
Inoue et al., "Circulating levels of soluble Fas ligand and soluble Fas in patients with chronic obstructive pulmonary disease," Respiratory Medicine, vol.
New sections were prepared for the immunohistochemical analysis of markers of apoptosis (Fas, Fas ligand, and BID), antiapoptosis (BCL-2, MCL-1), cell proliferation (Ki-67), and antiproliferation (p27Kip1) in thyroid cells and intrathyroidal lymphocytic infiltrate, as well as an evaluation of the lymphocytic infiltrate pattern in haematoxylin-eosin (HE) stained cells by an experienced pathologist.
Nagata, "Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing," The Journal of Experimental Medicine, vol.
Bloom, "Cloning and potential utility of porcine Fas ligand: overexpression in porcine endothelial cells protects them from attack by human cytolytic cells," Xenotransplantation, vol.
Endogenous decoy receptor 3 blocks the growth inhibition signals mediated by Fas ligand in human pancreatic adenocarcinoma.
As shown in Table 3, IRF1 and ZNRD1 are coexpressed with 356 (FASLG; Fas ligand) and 5609 (MAP2K7; mitogen-activated protein kinase 7) in the influenza A pathways.
Fas, Fas ligand, cleaved caspase 8, and p38[alpha] were investigated as markers of the extrinsic apoptosis pathway, and cytochrome C was selected as a marker of the common apoptosis pathway.
Munoz-Garcia et al., "NF-[kappa]B activation and Fas ligand overexpression in blood and plaques of patients with carotid atherosclerosis: potential implication in plaque instability," Stroke, vol.
Minatoguchi et al., "Plasma soluble Fas and soluble Fas ligand in chronic glomerulonephritis," Nephron, vol.
Apoptosis may be initiated by many factors, including circulating glucocorticoid levels, pro-inflammatory cytokines such as TNF-[alpha], interleukin-1, interleukin-6, FAS ligand, heat shock proteins, oxygen free radicals, nitric oxide and cytotoxic T lymphocytes; all of these factors are activated in sepsis.
They also measured increases in plasma nitric oxide levels and decreases in asymmetrical dimethylarginine, thiobarbituric acid reactive substance, soluble Fas ligand, soluble CD40 ligand, tumor necrosis factor-alpha, interleukin (IL)-6 and IL-8.
Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expression.