promotes apoptosis through the extrinsic pathway, after binding to Fas ligand (FasL).
Immediately after Fas-L and Fas interact, the apoptotic signal is transmitted through Fas DD to the adaptive protein associated to death domains (FADD) once the Fas receptor
(2008) Fas receptor
expression in germinal-center B cells is essential for T and B lymphocyte homeostasis.
Indeed, activated T and B lymphocytes express Fas receptor
and thus are sensitive to Fas receptor
mediated apoptosis [9, 10].
An enzymatically exfoliated extracellular domain of Fas receptor
(sFas) is present in the body fluids, but its role is not well known yet.
The many roles of FAS receptor
signaling in the immune system.
Keratinocyte may induce FasL expression via pro-inflammatory cytokines and the ligand is going to bind to Fas receptor
. Fas receptor
then recruits Fas-associated death domain protein (FADD) and pro-caspase 8.
For instance, Artepilin C (3,5-diprenyl-4-hydroxycinnamic acid) exhibits potent cytocidal effects and induces marked levels of apoptosis which may be partially associated with enhanced Fas receptor
expression and loss of the mitochondrial membrane potential in human leukemia cell lines in vitro (Kimoto et al., 2001).
TEHRAN (FNA)- Cancer cells - and not normal cells - can be killed by eliminating either the FAS receptor
, also known as CD95, or its binding component, CD95 ligand, scientists demonstrated.
Nagata, "Necrotic death pathway in Fas receptor
signaling," Journal of Cell Biology, vol.
For example, if a guanine (G) is replaced by an adenine (A) at position -670, the resulting polymorphism increases the binding affinity of the transcription factor STAT-1 for the interferon gamma-activated sequence (GAS), which in turn alters the transcription rate of the Fas receptor
The Fas/FasL system is implicated in the aetiology of IBD because the Fas receptor
(also called CD95, APO-1/Fas, or TNFRSF6) is highly expressed in the basolateral membrane of intestinal epithelial cells.