Chris Fantetti, 26, suffers with over 1,000 fasciculations
- erratic muscle jerks that look like insects under the surface of his skin - every day and says his life has been ruined by the rare condition.
On examination, fasciculations
on his lower extremities were observed (Video 1).
, Peripheral nerve hyper-excitability, Voltage gated potassium channels.
Involuntary activity like fibrillations, positive sharp waves, and fasciculations
were noted during rest while shape, size and recruitment patterns of motor unit action potentials were observed during voluntary muscle activation.
This causes a spectrum of muscle activity ranging from bronchospasm, skeletal muscle fasciculations
, tetany, and eventual complete fatigue and skeletal muscle paralysis, depending on the dose of nerve agent absorbed.
Signs of central nervous system (CNS) impairment (coma, somnolence, fasciculations
) and bleeding showed the strongest interdependence with clinical outcome (Table 1).
Her motor exam revealed no obvious muscle wasting, fasciculations
, or abnormal movements with intact and symmetric reflexes.
At various time points throughout the study, self-limiting, transient (< 1 minute), generalized or palpebral muscle fasciculations
were noted in 7 of 10 birds in A15.
Rocuronium has evolved as an acceptable alternative when succinylcholine is contraindicated due to side effects like severe hyperkalaemia in burns patients, bradycardia with 2 nd dose of succinylcholine, disease or denervation of muscle membranes, conditions with increased intragastric, intraocular and intracranial pressures and also postoperative myalgias due to fasciculations
or when there is absolute need for rapid sequence intubation or an anticipated difficult airway along with contraindications to succinylcholine.
The clinical picture is characterized by extensive though asymmetrical amyotrophy, fasciculations
, weakness, reactivity of myotatic reflexes, and a combination of bulbar and pseudobulbar syndromes, with preservation of both sensation and mentation, as well as ocular motility and sphincter control, although the latter is impaired in advanced stages.
The diagnosis of OPP solely depended upon: (1) evidence or history of exposure to OPCs within the previous twenty-four hours; (2) the odor of OPCs in the gastric contents; (3) distinctive signs of OPP, including meiosis, fasciculations
and excessive salivation (4) improvement of the signs and symptoms of OPP after administration of high doses of atropine and/ or pralidoxime.
were seen in the right upper extremity.