After the anticancer drug delivery systems were internalized into lung carcinoma (A549) cells by a lysosomal pathway (pH = 4.5-5.0), the ferrocenyl moieties were oxidized to ferrocenium
ions by nanoceria caps, which triggered the uncapping of nanoceria and caused the drug release, and at the same time, nanoceria exhibited cytotoxicity under acidic conditions while exhibiting a synergistic antitumor effect with the antitumor drugs.
These results are consistent with the known reactivity of ferrocene (and many other organometallic complexes) with any reducing species, where the reaction involves the formation of ferrocenium
. Therefore, the reactivity of the herein studied molecules will depend on the interactions occurring in the metal of the complex with other species.
In related work, physicist Silvia Mittler, MCIC, working with chemist Zhifeng Ding, MCIC have characterized the electrochemistry of self-assembled monolayers (SAMs) of monomeric calixarenes and heterodimeric calyxarenes capsules filled with ferrocenium
on Au surfaces for data storage purposes.
Theapproach adopted here was that described previously, (30) whereby the potential of a Ag wire pseudo-reference electrode was calibrated with respect to the redox potential of ferrocenium
(Fc+)/ferrocene (Fc), since the redox potential of this couple is generally regarded as independent of solvent.
and Ryabow A.D., 1997, "Regulatory role of surfactants in the kinetics of glucose oxidase catalyzed oxidation of D-glucose by Ferrocenium
and n-butyl ferrocenium
ions, Russian Chemical Bulletin", 46(10), 1700-1706.
Osella, Water stability and cytotoxic activity relationship of a series of ferrocenium
derivatives, ESR insights on the radical production during the degradation process, J.
Ferrocene is known to readily form charge transfer complexes (CTCs) with alkyl halides, as evidenced by the appearance of a feature indicative of a charge transfer complex at ~310 nm; subsequently, upon irradiation, the complex dissociates into the ferrocenium
ion, chloride ion, and alkyl radical (Fig.
Cavigiolio, On the mechanism of the antitumor activity of ferrocenium
The binding ratio of reduced and oxidized species reveals that ferrocenium
moiety interacts strongly with anionic DNA compared to ferrocene revealed by equation (1) .
salts are also attractive as photoinitiators for cationic polymerization because they possess absorptions in the middle region of the UV spectrum (10), (11).
So the obvious negative peak potential shift (cathodic shift) in the cyclic voltammogram for NPF by the addition of DNA is attributable to the electrostatic interaction of the positively charged nitrogen and ferrocenium
state of NPF with the polyanionic DNA.