The expression of several genes involved in iron metabolism including lactotransferrin, ceruloplasmin ferroxidase
, lipocalin 2 and ferroportin  upregulate during uterine growth and differentiation.
Whole cell protein was extracted and protein concentration was determined by Lowry method to proceed for ferroxidase
assay by using a method as previously described.
Induction of ferroxidase
enzymatic activity by copper reduces MPP+-evoked neurotoxicity in rats.
3+]) by the ferroxidase
activity of ceruloplasmin (Cp) and /or spontaneous oxidization and then bind to transferrin and to be acquired by the cells.
In human plasma, more than 95% of total copper is associated with ceruloplasmin (Cp), copper carrier and a ferroxidase
that is also responsible for iron metabolism, while less than 5% of copper ions are associated with other proteins (Heilman and Gitlin 2002).
Identification of Zyklopen, a new member of the vertebrate multicopper ferroxidase
family, and characterization in rodents and human cells.
(FeOx) activity of ceruloplasmin prevents OS by promoting the connection of free radicals from iron ions to transferrin.
Association of haptoglobin phenotypes with ceruloplasmin ferroxidase
activity in AY-thalassemia major.
Entretanto, estudos demonstram que esta ferroxidase
e eficaz para tal proposito em bovinos, aves e tambem equinos (MURATA et al.
Copper, another important trace element, joins to many Cu-dependent enzymes such as lysoyl oxidase (extracellular matrix protein cross-linking), cytochrome c oxidase (energy production), tyrosinase, dopamine-[beta]-hydroxylase, peptidoglycine alpha-amidating mono-oxygenase, and monoamine oxidase (pigment and neurotransmitter production and metabolism); copper-zinc superoxide dismutase and cerulo-plasmin is an [alpha]-2, copper transporting globulin synthesized in liver microsomes and possesses ferroxidase
Among the minerals required for skeletal formation, colloidal system maintenance, acid--base balance, and enzyme activities, Cu has been considered increasingly important in crustacean nutrition because of its functions in hematopoiesis and in numerous Cu-dependent enzymes including lysyl oxidase, cytochrome c oxidase, ferroxidase
, tyrosinase, and superoxide dismutase (SOD) (Lall 2002).
The H-subunit has a relatively acidic electrophoretic dynamism and acts as a ferroxidase
that oxidizes iron to ([Fe.