Colonoscopy revealed scattered areas of edema and colon biopsy showed severe vasculitis involving the small vessels of fragments of colonic mucosa and submucosa with leukocytoclastosis and fibrinoid necrosis
The dura may demonstrate inflammation with fibrinoid necrosis
The surface is ulcerated and covered by fibrin and/ or fibrinoid necrosis
overlying an exuberant granulation tissue.
An incisional biopsy of a l esion on the right leg showed necrotic skin with fibrinoid necrosis
and thrombosis of the blood vessels with little inflammation.
Intimal fibroplasia, lipohyalinosis, and fibrinoid necrosis
This necrosis was characterized by lymphocytic karyorrhexis in the white pulp, and fibrinoid necrosis
, congestion, and endothelial cell swelling in the red pulp, accompanied by cell debris.
A percutaneous renal biopsy was performed on fourth day of hospitalization, and histology showed a small-vessel vasculitis of the MPA type, characterized by transmural inflammation of the arterial wall, with a heavy infiltrate of neutrophils, eosinophils, and mononuclear cells, destruction of the blood-vessel wall, and segmental fibrinoid necrosis
Histologic examination reveals (1) a profuse fungal growth with tissue invasion, (2) non-caseating granulomas with multinucleated giant cells, (3) plasma cells, and (4) fibrinoid necrosis
Plexiform-like lesions and fibrinoid necrosis
were found at branch points of a few small arteries in 1 of these 3 cases (case 9) (Figure 6).
In the area of infiltration, several arterioles were seen with fibrinoid necrosis
of their walls (Figure 4).
Segmental areas of fibrinoid necrosis
with karyorrhexis were also seen in some of the glomeruli.
Renal biopsy, during which 24 glomeruli were examined including four cellular, six fibrocellular, and one fibrous crescent, revealed necrotizing crescentic pauci-immune glomerulonephritis with fibrinoid necrosis
in the capillary loops of some glomeruli.