fibrocyte


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fibrocyte

(ˈfaɪbrəˌsaɪt)
n
an inactive fibroblast
References in periodicals archive ?
A third SBIR will examine the potential for a newly discovered antigen-presenting cell, termed a fibrocyte, to be utilized as a cancer vaccine therapy.
The findings regarding the effects of PTX-2/SAP in the lung specific TGF1 transgenic mouse model expand on previous preclinical studies, in which Promedior investigators determined that PTX-2/SAP potently inhibited lung fibrosis in both acute bleomycin-induced pulmonary fibrosis models and chronic asthma models through an inhibition of pulmonary fibrocyte and pro-fibrotic (M2) macrophage activation and accumulation, associated with increased macrophage production of the regulatory cytokine IL-10.
Previous UMHS studies have demonstrated that the chemokine receptor CCR2 is a dominant receptor regulating fibrocyte recruitment to the injured or fibrotic lung.
After completion of dosing of the healthy volunteers, three patients with idiopathic pulmonary fibrosis were administered a single dose of 10mg/kg intravenously to confirm the safety, pharmacokinetics, and to assess the pharmacodynamic effects of PRM-151, on serum cytokine and fibrocyte biomarkers.
Pharmacodynamic indications of PRM-151's potential therapeutic efficacy will be explored throughout the study by assessment of specific plasma protein biomarkers and whole blood fibrocyte content, which have been associated with IPF pathology and disease progression.
4,5] Previous studies have demonstrated that BOO causes smooth muscle hypertrophy, fibrocyte hyperplasia and collagen deposition in the bladder wall.
Hank van Deventer shared how his recent cancer research NIH application for fibrocyte research was turned down during one of Smith's 18 rounds of chemotherapy.
The proposed cellular basis for NSF is the circulating fibrocyte (CF), which is a bone-marrow-derived, bloodborne, collagen-producing cell that normally provides a hematogenous source of connective tissue cells (fibroblasts, myofibroblasts) for reparative processes.
In a Phase 1 study in healthy volunteers and IPF patients, PRM-151 was safe and well-tolerated, and showed activity against efficacy biomarkers by reducing IPF-related peripheral blood fibrocyte and IL-6 levels.
Fibrocytes were identified and patented by the Picower Institute of Medical Research in Manhasset, N.
We believe this opens the door for a new and powerful way to regulate M2 macrophages and fibrocytes using Pentraxin-2-based therapeutics and a new path for discovering novel treatments for patients.
17364 - The Effects Of Recombinant Human Pentraxin-2, (PRM-151), On Circulating Fibrocytes In Idiopathic Pulmonary Fibrosis (IPF)
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