In a study by Seo and Choi (43), mouse raw 264.7 macrophage cells were treated with five flavonoids including EGCG, quercetin, fisetin
, daidzein and ECG.
Effects of two antioxidants; [alpha]-lipoic acid and fisetin
against diabetic cataract in mice.
This antioxidant's name is fisetin
. You'll find it in foods like strawberries, apples, persimmons, onions, and cucumbers.
The researchers of the study found that fisetin
, a polyphenol found in foods such as apples, strawberries, persimmons, onions, and cucumbers, reduced the burden of damaged cells and extended the lifespan of aging mice.
induces Nrf2-mediated HO-1 expression through PKC-S and p38 in human umbilical vein endothelial cells.
is a plant flavonoid, reported to have anti-allergic potential via inhibition of Th2 response.
Mango contains quercetin, isoquercitrin, astragalin, fisetin
, gallic acid and methylgallat, as well as the abundant enzymes.
Other flavonoids with antioxidant, anti-inflammatory, and neuroprotective effects have also been evaluated as potential antidepressant agents, one example of which is the flavonoid fisetin
. The administration of 10 and 20 mg/kg fisetin
(i.p.) significantly reduced total immobility time in the forced swim and tail suspension tests .
also summarizes in a review the in vitro and in vivo effects of fifteen Nrf2- (nuclear factor erythroid-derived 2-related factor 2 pathway-) interacting natural compounds (tocotrienols, curcumin, epigallocatechin gallate, quercetin, genistein, resveratrol, silybin, phenethyl isothiocyanate, sulforaphane, triptolide, allicin, berberine, piperlongumine, fisetin
, and phloretin) on cellular senescence and discusses their use in adjuvant cancer therapy.
Xie et al., "Fisetin
alleviates early brain injury following experimental subarachnoid hemorrhage in rats possibly by suppressing TLR 4/NF-[kappa]B signaling pathway," Brain Research, vol.
The chromatogram of MECN obtained from the HPLC analysis was compared against the chromatogram of several pure flavonoid-based bioactive compounds (i.e., fisetin
, quercetin, rutin, quercitrin, naringenin, genistein, pinostrobin, hesperetin, and dihydroquercetin) to determine their presence in the fraction.
* Strawberries: This berry is rich in the antioxidant fisetin
, a compound that has been found to have anti-cancer and neuroprotective properties.