The device takes advantage of a method developed earlier this decade to determine the length of DNA fragments tagged with fluorescent dyes
. Under laser light, the fragments fluoresce according to their length.
Supplies daylight fluorescent pigments and dyes, which include Z- and ZQ-Pigments for injection molding at 375 to 550 F; extra-strength ZX-Pigments for injection molding; extra-strength, low plateout NX-Pigments for blow molding; lightfast, heat stable fluorescent dyes
for PC, styrenics, acrylics, and engineering resins; lightfast, heat stable VC-Pigments for rigid and semi-rigid PVC calendering and extrusion; A- and AX-Pigments for plastisols and organosols; and PPG-Dispersions for foam and cast urethanes.
To streamline the analysis of these markers, Todd's group labeled 300 of them with fluorescent dyes
. These markers divide the human genome into sections of 20 million nucleotides.
Bayer proposed that fluorescent dyes
would provide the means for differentiating resins.
Using fluorescent dyes
to represent drugs, Langer's team delivered millisecond pulses of current every 5 seconds for an hour and monitored the dyes' passage through skin.
Lansing Taylor first decided to use fluorescent dyes
, he simply wanted to track the intracellular movements of a molecule called actin.
Today, laboratories typically screen for drugs with devices that use molecules labeled with radioactive tags or fluorescent dyes
. Many of these screening techniques harness antibodies, molecules that recognize specific substances--Even when those substances exist in minute amounts.
, microscopes and various kinds of illumination -- the sorts of things that could help him satisfy his curiosity -- represent integral parts of his daily routine.
As few as 10 to 20 fluorescent signals in a cell can be detected with LLLM, he says, and the average cell has 1 billion copies of actin that might someday be individually labeled with fluorescent dyes
. By labeling sub-units of actin and other proteins and then injecting them into cells, scientists can track microfilament and microtubule formation with precision, says Taylor.
In these experiments, models are towed along an 18-meter water channel in which fluorescent dyes
mark the flow patterns.