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A protease-inhibiting drug given in the form of its mesylate, used usually in combination with other drugs to suppress the replication of HIV.

[saquin- (perhaps alteration of (i)soquin(oline) : iso- + quinoline) + a(nti)vir(al).]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
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Noun1.saquinavir - a weak protease inhibitor (trade name Invirase) used in treating HIV
protease inhibitor, PI - an antiviral drug used against HIV; interrupts HIV replication by binding and blocking HIV protease; often used in combination with other drugs
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.


n saquinavir m
English-Spanish/Spanish-English Medical Dictionary Copyright © 2006 by The McGraw-Hill Companies, Inc. All rights reserved.
References in periodicals archive ?
The manufacturer, Roche, subsequently developed the Fortovase soft-gel capsule (SGC) formulation which has enhanced bioavailability but also significant gastrointestinal toxicity.
Some medications are crucial to health, like Invirase or Fortovase, two antiretroviral drugs given to people with HIV.
Table 1 Common Antiretroviral Drugs (14-16) Classification Generic Name Trade Name Nucleoside reverse Abacavir sulfate Ziagen transcriptase inhibitors Abacavir sulfate + Trizivir (NRTI) lamivudine + zidovudine Didanosine (ddl) Videx, Videx EC Lamivudine (3TC) Epivir Lamiudine + zidovudine Combivir Stavudine (d4T) Zerit Tenofovir disoproxil Viread fumarate Zalcitabine (ddC) Hivid Zidovudine (AZT, ZDV) Retrovir Non-nucleoside reverse Delavirdine mesylate Rescriptor transcriptase inhibitors Efavirenz Sustiva (NNRTI) Nevirapine Viramune Protease inhibitors (PI) Amprenavir Agenerase Indinavir sulfate Crixivan Lopinavir + ritonavir Kaletra Nelfinavir Viracept Ritonavir Norvir Saquinavir Fortovase Saquinavir mesylate Invirase Fusion inhibitors (FI) Enfuvirtide Fuzeon
* Roche announces it will stop making Hivid and Fortovase due to low demand; these are the first anti-HIV meds decommissioned.
* The FDA approves new formulation of saquinavir (Fortovase, a soft-gel formulation designed to improve absorption in the body).
1015, 2004) describes how loperamide significantly lowered the blood levels of Fortovase in 12 HIV-negative volunteers.
Both people who had the virologic failure were on Kaletra and saquinavir (either Invirase or Fortovase).
Saquinavir (Fortovase) comes in a vehicle containing glycerol monostearate, which is composed of mono- and diglycerides of hydrogenated vegetable oil.
The University of Sydney Table 1 Drugs whose metabolism is inhibited and bioavailability increased by grapefruit juice (6,7) Anti-hypertensive Calcium channel blockers FELODPINE ('Agon'; 'felodur'; 'Plendil' NIFEDIPINE ('Adalat'; 'Nyefax') NISOLDIPINE NITRENDIPINE NIMODIPINE ('Nimotop') Certain HMG CoA Reductase inhibitors SIMVASTATIN ('Lipex'; 'Zocor') LOVASTATIN ATORVASTATIN ('Lipitor') Immunomodifiers CYCLOSPORIN ('Neoral') TACROLIMUS ('Prograf') An Anti-convulsant CARBAMAZEPINE ('Tegretol') Certain Benzodiazepine sedatives MIDAZOLAM ('Hypnovel') TRIAZOLAM ('Halcion') Certain Anti-viral agents INDINAVIR ('Crixivan') SAQUINAVIR ('Invirase'; 'Fortovase') GI Motility stimulant CISAPRIDE ('Prepulsid') An Azopirone Anxiolytic BUSPIRONE ('Buspar') (9)
Pls--Agenerase, Crixivan, Kaletra, Viracept, Norvir, Fortovase, Invirase
Fortovase, the soft gelatin capsule formulation of saquinavir (with tenfold greater bioavailability), became available in 1997.
saquinavir (Fortovase, Invirase) levodopa (Atamet, Larodopa) Treats Parkinson's Disease.