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High viral load, previous fosamprenavir use and more recent HIV diagnosis correlate with darunavir failure in salvage therapy in Sao Paulo, Brazil.
Long-term virologic and immunologic responses on darunavir/ritonavir--containing regimens among highly antiretroviral therapy-experienced patients: 7-year follow-up of a prospective cohort study in Sao Paulo, Brazil
Atazanavir (Reyataz[R]), darunavir (Prezista[R]), fosamprenavir (Lexiva[R], Telzir[R]), indinavir (Crixivan[R]), lopinavir and ritonavir combination (Kaletra[R]), nelfinavir (Viracept[R]), saquinavir (Invirase[R], Fortovase[R]), and tipranavir (Aptivus[R]) are PIs (AIDSinfo, 2016; FDA, 2016).
Antiviral Medications, Part 2: HIV Antiretroviral Therapy
Contract award notice: Medicamento: Abacavir/Lamivudina, Fosamprenavir, Zidovudina/Abacavir/Lamivudina.
140532-2017
20) This University of Sao Paulo group gives the second-generation PIs--ritonavir-boosted lopinavir, amprenavir, fosamprenavir, and tipranavir--the worst dyslipidemia marks in their Table 2 summary: three up-arrows indicating the greatest likelihood of spawning dyslipidemia.
Lipid impact on HIV heart disease, and antiretroviral impact on lipids
Co-administration of moderate (diltiazem, erythromycin, fluconazole, fosamprenavir, verapamil) or strong (eg, ketoconazole, clarithromycin, nefazodone, ritonavir) CYP3A4 inhibitors increases the concentration of flibanserin.
Flibanserin for hypoactive sexual desire disorder in premenopausal women: flibanserin has shown moderate efficacy in improving low sexual desire, however, it is contraindicated with alcohol use
The PIs used were nelfinavir until 2007, saquinavir, fosamprenavir, lopinavir, atazanavir and, from 2009, darunavir.
Birth outcome in HIV vertically-exposed children in two Romanian centers
Moderate CYP3A4 inhibitors include amprenavir, atazanavir, ciprofloxacin, diltiazem, erythromycin, fluconazole, fosamprenavir, verapamil, and grapefruit juice.
What you need to know (and do) to prescribe the new drug flibanserin: 11 questions and answers highlight indications, risks, adverse reactions, and requirements for prescribers
Las mutaciones I50V e I54L incrementan la susceptibilidad a tripanavir (TPV), N88S incrementa la susceptibilidad a fosamprenavir y L76V incrementa la susceptibilidad a atazanavir, saquinavir y tripanavir (42); mientras que V82A/T/F/S y I84V estan asociados a resistencia a todos los inhibidores de proteasa, resaltando por ser mutaciones con un alto grado de polimorfismo (37).
Resistencia a antirretrovirales: bases moleculares e implicaciones farmacologicas
FDA-Approved Antiretroviral Agents Nucleoside RTIs Nonnucleoside RTIs Protease inhibitors abacavir (ABC) delavirdine (DLV) atazanavir (ATV) didanosine (ddl) efavirenz (EFZ) darunavir (DRV) emtricitabine (FTC) etravirine (ETV) fosamprenavir (Fos-APV) lamivudine (3TC) nevirapine (NVP) indinavir (IDV) stavudine (d4T) lopinavir/r (LPV/r) zidovudine (ZDV) nelfinavir (NFV) ritonavir (RTV) saquinavir (SQV) tipranavir (TPV) Nucleotide RTI Integrase inhibitor Fusion inhibitor tenofovir DF (TDF) raltegravir (RAL) enfuvirtide (T-20) CCR5 antagonist maraviroc (MVC) Notes: Six fixed-dose combinations are approved by the Food and Drug Administration.
New guidelines endorse earlier HIV treatment: treatment should be considered in asymptomatic patients with a CD4 cell count above 500/mcL
The 2008 IAS-USA guidelines (8) for initial antiretroviral therapy recommend either of two basic three-drug regimens: efavirenz plus two NRTIs, or a ritonavir-boosted protease inhibitor (lopinavir, atazanavir, fosamprenavir, darunavir or saquinavir) plus two NRTIs.
HIV post-exposure prophylaxis and antiretroviral therapy for adults and adolescents: a practical guide for surgeons and general practitioners: as HIV has become a chronic manageable condition, with patients living longer, so the risk of transmission to health care workers has potentially increased
En el tratamiento para la infeccion por VIH, los IP tales como el lopinavir, el saquinavir y el fosamprenavir pueden inducir el desarrollo de dislipidemia con predominio del aumento de trigliceridos y LDL-c (25, 26) A su vez, el atazanavir, no causa ningun cambio desfavorable de lipidos (28).
Efecto de la terapia antirretroviral sobre el perfil lipidico de pacientes con Sida en Maracaibo, estado Zulia, Venezuela
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