In the United States G6PD
deficiency is present in about 12 percent in African-American men.
is the principle source of NADPH which is of central importance to cellular redox regulation and any changes in G6PD
will alter NADPH levels, thus impact the entire antioxidant system and makes tissues very vulnerable to oxidative damage .
This drug can accelerate the hemoglobin reduction process through the NADPH-dependent G6PD
Some antibiotics taken by breastfeeding mothers may occasionally be associated with adverse effects in their infants: TMP/SMX may cause poor feeding; amoxicillin and cephalexin may cause diarrhea; nitrofurantoin may cause diarrhea or, in infants with G6PD
deficiency, hemolytic anemia; and ciprofloxacin may cause pseudomembranous colitis in infants and green teeth in neonates (SOR: C, case reports and expert opinion).
is not a uniquely Filipino disease, and in the Philippines it has higher incidence in areas like the Cordillera because it gives people a certain degree of protection from malaria, a disease which is endemic in that region.
Factors increasing serum bilirubin in newborns Increased destruction * G6PD
dysfunction of red blood cells * Untreated rhesus incompatibility * ABO group incompatibility * Genetic blood cell defects * Sepsis * Birth trauma with haematoma formation Decreased plasma * Prematurity albumin concentration * Infection or illness * Competition for binding sites by drugs, eg sulphon amides, salicylates Decreased conjugation * Immature enzyme systems in liver * Genetic disorders * Inhibition by drugs eg amitriptyline, ketoconazole Increased reabsorption * Dehydration from gut * Constipation * Immature gut with poor motility * Breastfeeding
Other causes in their study were G6PD
deficiency, hypothyroidism, UTI, septicaemia, Down syndrome & ABO incompatibility.
According to the latest statistics from the OHBDA, Thalassaemia is carried by up to a staggering 50 per cent of the Omani population, and G6PD
by 35 per cent.
In "Answering your questions" (Tips, November 2010, page 32) regarding G6PD
To avoid these severe side effects, Bactrim should not be given to patients with a known sulfa allergy or G6PD
High-dose intravenous vitamin C is therefore contraindicated in people with G6PD
deficiency, and patients should be tested for this condition before receiving such treatment.
5) Exchange transfusion should be considered in G6PD