and HNF1A mutations are responsible for the majority of MODY cases.
In MODY, genetic analysis was available in 26 (59%) patients and HNF1A and GCK
gene mutations were detected in 3 (11.5%) and 14 (53.8%) patients, respectively.
The cDNA probes for detecting apolipoprotein E (Apoe), fatty acid synthase (Fas), Gck
, insulin-like growth factor-binding protein (Igfbp-1), and Pck1 genes have been published previously (23).
 Human Genes: PPAR, peroxisome proliferator activated receptor family; MEST, mesoderm specific transcript; LEP, leptin; FTO, [alpha]-ketoglutarate dependent dioxygenase; HNF1A, hepatocyte nuclear factor 1 homeoboxA; HNF4A, hepatocyte nuclear factor 4a; GCK
, glucokinase; HNF1B, hepatocyte nuclear factor 1 homeoboxB; KCNJ11, potassium voltage-gated channel subfamily J member 11; TRIM28, tripartite motif containing 28.
MODY = Mature Onset Diabetes of the Young; HNF = Hepatocyte Nuclear Factor; GCK
= glucokinase; TG = triglyceride; LDL = low density lipoprotein; HDL = high density lipoprotein; VLDL = very low density lipoprotein; Apo = apolipoprotein.
The chance of the fetus inheriting the paternal GCK
mutation was equally 25%.
ER: endoplasmic reticulum; eEF1A: eukaryotic elongation factor 1A; GcK
: glucokinase; GLUT2: glucose transporter 2.
The primer PCR efficiency (E) was calculated for each gene fluorescence curve with LigRegPCR 12.18 software (Udvardi et al., 2008), and the efficiency rates for the transcripts were as follows: 1.96 for gh, 1.87 for igf-1, 1.91 for tg, 1.8 for igfbp, 1.82 for igf-1r(a/b), 1.7 for gck
, 1.88 cck, 1.96 ghrelin and 1,84 for efl[alpha] over the entire quantification range.
* How do teacher demographics and GTBS (Beliefs, Confidence, and Motivation) and the TPACK-G constructs (GK, GPK, and GCK
) predict in-service teachers' GPCK?
mRNA expressions of some glycolytic genes, including Pdkl, Pgkl, Glutl, Gck
, and Pkm2, were higher in peritoneal macrophages isolated from the Lysm HIF1[alpha] lsl mice than in the WT mice at both 6 h and 24 h (Figures 4(a) and 4(b)).
[ACE2.sup.-/y] mice presented a reduction in the relative expression of glucokinase (GCK
) and of glucose transporter type 2 (GLUT2) and increased levels of expression of glucose 6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase subtype 2 (PCK2).