ATF

(redirected from GDNF)
Also found in: Thesaurus, Medical, Financial, Acronyms, Encyclopedia.
Related to GDNF: CNTF

ATF

abbr.
Bureau of Alcohol, Tobacco, Firearms and Explosives
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.ATF - the law enforcement and tax collection agency of the Treasury Department that enforces federal laws concerning alcohol and tobacco products and firearms and explosives and arson
Department of the Treasury, Treasury Department, United States Treasury, Treasury - the federal department that collects revenue and administers federal finances; the Treasury Department was created in 1789
law enforcement agency - an agency responsible for insuring obedience to the laws
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
(28) After hASCs transplantation, AD mice models showed increased VEGF, GDNF, NT-3, and anti-inflammatory cytokine IL-10, while IL-1[beta] remained unchanged.
Half of the patients were given monthly GDNF infusions and half received monthly placebo infusions.
A specially designed delivery system was designed to get GDNF to the brain cells that need it.
The multimillion-pound study, funded by Parkinson's UK with support from The Cure Parkinson's Trust, aimed to investigate whether boosting the levels of GDNF can regenerate dying brain cells in people with Parkinson's and reverse their condition, which is something that no existing treatment can do.
Results: In case group, serum NGF and GDNF levels were found to be significantly higher in females than males (p = 0.042, p = 0.031).
The researchers demonstrated that both FGF2 and glial cell line-derived neurotrophic factor (GDNF) are indispensable for SSC self-renewal and survival in vitro, FGF2 showed different properties from GDNF in mouse testis.
Neurotoxicity assays based on neurite outgrowth dynamics For the NeuriTox test, LUHMES cells were differentiated for 48 h and seeded into 96 well plates at a density of 100,000 cells/[cm.sup.2] in a volume of 90 [micro]l DM without cAMP and GDNF. Treatment was initiated applying 10 [micro]l of a 10x concentrated treatment solution one hour after seeding.
In a previously published report of this neuropathological cohort, the team examined a number of markers of neurodegeneration including S100B, the soluble form of the receptor for advanced glycation end-products (sRAGE); glial cell-derived neurotrophic factor (GDNF); and amyloid beta (AB) 40 and AB42 (J Alzheimers Dis.
This idea is further corroborated by studies involving the secreted neural signaling molecules PACAP and GDNF, both of which have migratory and proliferative effects on germ cells in vitro [53-55].
Typically, such methods rely on growth factors and various small molecules including basic fibroblast growth factor (bFGF) [61, 62], epidermal growth factor (EGF) [63], nerve growth factor (NGF) [62, 64], brain-derived neurotrophic factor (BDNF) [65], glial cell line-derived neurotrophic factor (GDNF) [66], sonic hedgehog [66], neurotrophin 3 (NT-3) [61], retinoic acid (RA) [63], forskolin [50, 67], and heparin [66] as well as culture supplements such as B27 [61], insulin-transferrin-sodium selenite (ITS) [54], nonessential amino acids [66], and N2 [61, 66].
We found significant differences in six: NGF (p < 0.001), NGFR (p < 0.05), NTRK1 (p < 0.01), GFRA1 (p < 0.01), GFAP (p < 0.001), and GDNF (p < 0.05) (see Figure 2).
Glial cell line-derived neurotrophic factor (GDNF) is a member of the neurotrophin family, and it is responsible for neuronal survival by protecting neurons from damage [13].