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This is highlighted by the recently identified human mutation in GUCY2C, the gene encoding GC-C and its consequent association with chronic diarrhea and increased risk for inflammatory bowel disease, small-bowel obstruction, and esophagitis (71).
In this system, prouroguanylin is converted to uroguanylin in the central nervous system , activates guanylyl cyclase 2C (GUCY2C) receptors in the brain to reduce food intake in mice.
The active uroguanylin was then found to bind to proteins on nerve cells known as GUCY2C receptors, triggering a cascade of events that led to decreased food intake.