AMAN has been strongly associated with antibodies to gangliosides
GM1 and GD1a in axons of peripheral nerves3.
Avian influenza A viruses differ from human viruses by recognition of sialyloligosaccharides and gangliosides
and by a higher conservation of the HA receptor-binding site.
It consists of complex bioactive components such as phospholipids, sphingolipids, gangliosides
and proteins,' Andersen said.
Pre-clinical data in animal models of GM1 show that LYS- GM101 treatment delivers a functional gene encoding the [sz]gal enzyme resulting in a reduction of GM1 gangliosides
and transforms the animal phenotype.
Sialic acid is an essential component of brain gangliosides
that impact cell to cell communication in the nervous system.
Degradation of gangliosides
by the lysosomal sialidase requires an activator protein.
Zika virus and neurologic autoimmunity: the putative role of gangliosides
Potent GCS inhibitors reduce glucosylceramide (GlcCer), the substrate of GBA and the storage material in Gaucher, and also higher glycosphingolipids including gangliosides
and globosides, the causative storage materials in Tay-Sachs disease, GM1 gangliosidosis and Fabry disease.
Yamakawa had spent a sabbatical in Ernst Klenk's laboratory in Cologne working on gangliosides
In several studies, immunoglobulin antibodies produced against GM1, GM1b, and GD1a gangliosides
were obtained from serous fluids of cases and it was suggested that these antibodies were generated against the membrane liposaccharides of Campylobacter jejuni, showing cross-reactivity with gangliosides
in the node of Ranvier.
The discovery of bioactive compounds and therapeutic properties isolated from sea cucumber such as chondroitin sulfate, triterpene glycosides (saponins), lectins, heparin, cerebrosides, gangliosides
, bioactive peptides, sterols, and omega-6 and omega-3 fatty acids leads to potential drug development in various pharmaceuticals, agrochemicals, functional foods, and nutraceuticals industries.
Next steps include examining the role of other growth factors and gangliosides