2) They may present as single or multiple lesions and may either be solitary or manifest as part of a syndrome such as Gardner Syndrome
Acrochordons are associated with type 2 diabetes mellitus, insulin resistance, obesity, dyslipidaemias, pregnancy, genetic predisposition, human papilloma virus 6 and 11, acromegaly, Gardner syndrome
, Birt-Hogg-Dube syndrome and Nonne-Milroy-Meige syndrome.
Because Gardner syndrome
may include different organs, it is generally very tough to treat it, and the therapeutical effect is also doubtful.
Multiple epidermal cysts may be associated with Gardner syndrome
, which is an autosomal dominant disease characterized by cutaneous lesions, osteomas, and intestinal polyposis.
The familial occurrence of pilomatrixoma has been described, (15) and multiple pilomatrixomas have been associated with myotonic dystrophy, (15) Gardner syndrome
, (6) Rubinstein-Taybi syndrome, (16) and other conditions.
1,2,3) Multiple lesions are reportedly present in 2-10% of cases, and are associated with Gardner Syndrome
, Turner Syndrome, myotonic dystrophy and sarcoidosis.
Cutaneous nodules are found in many other disorders, including Gardner syndrome
, Cowden syndrome, multiple trichoepitheliomas, (32) basal cell nevus syndrome, (33) multiple keratoacanthomas, (34) and tuberous sclerosis (35) (Table).