Key secondary and exploratory endpoints include normalization of urinary glycosaminoglycans
, growth velocity and effects on motor and cognitive function at one- and two-years post-treatment.
MPS is characterized by the accumulation of glycosaminoglycans
("GAGs"), polysaccharides which are important for the modulation of cellCaetoCaecell signaling and the maintenance of tissue structure and function, in the lysosomes of cells.
It causes an enzyme deficiency that interferes with the body's ability to break down certain complex sugar polymers called glycosaminoglycans
, resulting in serious skeletal, tissue, neurological and multi-organ complications and, ultimately, a shortened lifespan.
leverages its proprietary technology platform in the hyaluronan and glycosaminoglycans
to develop products that address unmet needs for patients in Dermatology Oral Care and Osteoarthritis BMG Pharma S.p.A.
discovered that the glycosaminoglycans
found in atrophoderma of Pasini and Pierini were different from the ones observed in morphea (3).
, chondroitin, green-lipped mussel extract or omega-3 fatty acids for arthritis).
M2 PHARMA-September 6, 2018-Sangamo Releases 16 Week Clinical Results Including Reductions in Glycosaminoglycans
in Phase 1/2 Trial Evaluating SB-913 in Hunter Syndrome
(GAGs) are highly negatively charged sugar chains that are covalently bound to a protein core to form aggrecan, which is one of the primary matrix molecules of cartilage.
Satta et al., "Quali-quantitative analysis of urinary glycosaminoglycans
for monitoring glomerular inflammatory activity," Scandinavian Journal of Urology and Nephrology, vol.
Their valves provided a snapshot of early CAVD that is challenging to capture in humans, showing that it typically begins with the accumulation of certain sugar molecules called glycosaminoglycans
(GAGs) in valve tissue.
For healthy cartilage, your dog needs hyaluronic acid, collagen, and glycosaminoglycans