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 (hī′pō-gō′năd-ĭz′əm, -gŏn′ə-dĭz′əm)
Inadequate functioning of the testes or ovaries as manifested by deficiencies in gametogenesis or the secretion of gonadal hormones.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(ˌhaɪ pəˈgoʊ næˌdɪz əm, -ˈgɒn æ-)

n. Pathol.
1. diminished hormonal or reproductive functioning in the testes or the ovaries.
2. a manifestation of this, as delayed pubescence.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.hypogonadism - incompetence of the gonads (especially in the male with low testosterone); results in deficient development of secondary sex characteristics and (in prepubertal males) a body with long legs and a short trunk
eunuchoidism, male hypogonadism - the state of being a eunuch (either because of lacking testicles or because they failed to develop)
Kallman's syndrome - hypogonadism with anosmia; a congenital sexual disorder that prevents the testicles from maturing at puberty
incompetence - inability of a part or organ to function properly
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
Physical examination findings, pubertal status and secondary sex characteristics, presence of gonadal failure and gynecomastia were investigated.
Approximately 1% of females experience premature ovarian insufficiency, which can be diagnosed as early as age 14 years and should be suspected in a patient with a uterus but without breasts who has low estradiol levels, CNS failure identified by a high FSH level, and gonadal failure.
* Assessment of gonadotropins (LH, FSH) is helpful for determining the cause of established gonadal failure because their increase is usually clear cut.
Complications of thalassemia include transfusion related infections as hepatitis C, HIV, complications due to iron overload which include cardiac complications like hypertrophic cardiomyopathy, arrhythmias, and cardiac failure and endocrinopathies like hypothyroidism, hypoparathyroidism, gonadal failure, pubertal delay, short stature and diabetes mellitus5,6.
Special investigations showed a follicle-stimulating hormone level of 66.5 IU/L and an oestradiol level of <73 pmol/L, in keeping with primary gonadal failure. Her serum testosterone level was significantly elevated at 5.4 nmol/L.
The gynecomastia could be explained by 17-[beta]-HSD3 deficiency and the high FSH and LH levels, which indicated primary gonadal failure. As this patient had significant gynecomastia with low testosterone, he was given testosterone injections, 50mg once a month, for a total of six months.