GeoVax Labs announced that Harriet Robinson, PhD, CSO Emeritus and Director of the Company's HIV Vaccine program, delivered an oral presentation entitled, Protein-Supplemented DNA/MVA Vaccines: Preclinical Immunogenicity and Protection for Transmitted/Founder and CD4-induced gp120
Proteins, during the 10th International AIDS Society Conference.
Delineation of a region of the human immunodeficiency virus type I gp120
glycoprotein critical for interaction with the CD4 receptor.
HIV dendritik hucreler icerisinde lenfoid organlara tasinir, uzerinde bulunan glikoprotein yapidaki reseptor gp120
sayesinde CD4+ T hucrelerine girerek hucrenin genomuna yerlesir.
In the 35 years of the HIV epidemic, only four HIV vaccine concepts have been tested in humans, and only one has provided evidence of protection in an efficacy trial -- a canarypox vector prime, gp120
boost vaccine regimen tested in the RV144 trial in Thailand lowered the rate of human infection by 31% but the effect was considered too low to advance the vaccine to common use.
reported that HIV-1 clade B has increased resistance towards the bnAbs targeting gp120
as shown by VRC01, NIH45-46, PG9, PG16, PGT121, and PGT128 .
Similarly, envelope glycoprotein 120 (gp120
) induces dysregulation of calcium homeostasis, increases oxidative stress, and drives apoptosis in neurons [185, 189].
The binding of HIV-1 envelope glycoprotein gp120
to CCR5 leads to PLC[beta]-1 nuclear localization which promotes the release of chemokine CCL2 by macrophages , suggesting that activation of PLC[beta]-1 signaling stimulates the expression of CCL2 in macrophages.
That HIV shield covering the virus includes a protein called gp120
, which in turn is covered by a layer of sugar.
The protein fragment of the vaccine candidate comes from gp120
, a protein that covers HIV like a protective envelope.
In this trial (HVTN 114), these "late boosts" consist of the GeoVax MVA62B vaccine with or without a gp120
The improved vaccine consists of a canarypox-based vaccine called ALVAC-HIV and a bivalent gp120
protein subunit vaccine with MF59, a different adjuvant from that used in the Thai trial, in an effort to achieve a more robust immune response.
Aunque se sabe que el VIH puede infectar las neuronas, el mayor dano lo hace de manera indirecta, al aumentar el ambiente proinflamatorio con marcadores como la interleucina 1 y el factor de necrosis tumoral alfa, mediante la interaccion de sus distintas proteinas y glicoproteinas (de las cuales una de las mas estudiadas es la gp120