All other antimicrobials not mentioned in this study were excluded because they are not used for treating infections caused by Gram-negative bacteria
or have only a minimal effect on Gram-negative bacteria
and the appearance of resistance in these bacteria in the gut.
Learning more about how Gram-negative bacteria
communicate with each other can help researchers build a stronger understanding of multispecies interactions and how to eventually control these types of high-risk infections.
This funding supports the development of ATI-1503, an antibiotic targeting drug-resistant Gram-negative bacteria
, including Klebsiella pneumoniae, Acinetobactor baumannii, and Pseudomonas aeruginosa.
Redx will receive the funds over 18 months, with an option for future tiered milestone payments, to drive scientific progress against globally challenging drug resistant Gram-negative bacteria
. This partnership with CARB-X allows Redx to move its Gram-negative program into the next stage of development with a prospective partner.
The most common gram-positive bacteria causing septicemia infection was Staphylococcus aureus 22(28.20%) followed by coagulase-negative Staphylococcus (CONS) 9(11.53%).In gram-negative bacteria
Escherichia coli 19(24.35%) was the most common pathogen following Enterobacter 10(12.82%), Proteus spp.8(10.25%), Psudomonas 5(6.41%), Klebsiella 1(1.28%) and Acinetobacter 4(5.12%) (Table 1).
Onuchic and CTBP colleagues Eshel Ben-Jacob and Patricia Jennings reached their conclusions after analyzing several studies on anti-microbial peptides (AMPs), corkscrew-shaped chains of amino acids that kill Gram-negative bacteria
. The CTBP team's ideas appear this week in the Proceedings of the National Academy of Sciences (PNAS) as a commentary on new findings from MD Anderson Cancer Center about a promising synthetic AMP called D-KLAKLAK-2.
Objective: Extended spectrum ss-lactamases (ESBLs) represent a major group of lactamases currently being identified in large number worldwide mostly produced by gram-negative bacteria
. The present study was done to see the frequency of ESBLs in gram-negative bacterial isolates causing nosocomial wound infections from a tertiary care hospital in Bangladesh.
It provides predominantly a spectrum of activity against Gram-positive and Gram-negative bacteria
. In formulations tested, NataPres demonstrated activity against fungi and yeast when used at typical levels.
Histopathology revealed severe fibrinonecrotic enteritis associated with large numbers of gram-negative bacteria
, multifocal fibrinoid necrosis in portal arteries, accumulation of fibrin in hepatic sinusoids, myocardial degeneration, and necrosis.
Total sebum lipids (2- 4 mg/ml), sonicated into bacterial culture medium, caused 4- to 5-fold log reduction in growth of gram-positive bacteria, Staphylococcus aureus, Streptococcus salivarius and the anaerobe Fusobacterium nucleatum, but was ineffective against most gram-negative bacteria
. Fractionation of the sebum lipids showed that both saturated and unsaturated fatty acids contained the bulk of the antimicrobial activity.
(Foster City, CA) has patented a method and a composition for treatment of pulmonary bacterial infections caused by gram-negative bacteria
suitable for treatment of infection caused by Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, Serratia marcescens as well as those caused by Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans, and multidrug resistant Pseudomonas aeruginosa, using a concentrated formulation of aztreonam lysinate delivered as an aerosol or dry powder formulation.