granulocyte-macrophage colony-stimulating factor

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Related to Granulocyte macrophage colony-stimulating factor: colony stimulating factor 2

granulocyte-macrophage colony-stimulating factor

n. Abbr. GM-CSF
1. A cytokine secreted by a variety of cell types that stimulates progenitor cells in the bone marrow to produce granulocytes (especially neutrophils) and macrophages.
2. A recombinant form of this cytokine, such as the drug sargramostim.
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Melapuldencel-T - an irradiated autologous in vitro proliferating melanoma cell line loaded onto an autologous dendritic cell combined with granulocyte macrophage colony-stimulating factor (GMCSF) - has been approved to enter a Phase 3 clinical trial with Special Protocol Assessment (SPA) and received fast track designation for metastatic melanoma, as well as orphan drug designation.
Melapuldencel-T - an irradiated autologous in vitro proliferating melanoma cell line loaded onto an autologous dendritic cell combined with granulocyte macrophage colony-stimulating factor (GM-CSF) - has been approved to enter a Phase 3 clinical trial with Special Protocol Assessment (SPA) and received fast track designation for metastatic melanoma, as well as orphan drug designation.
NeuVax consists of the E75 peptide derived from human epidermal growth factor receptor 2 (HER2) combined with the immune adjuvant granulocyte macrophage colony-stimulating factor (GM-CSF).

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