heavy chain

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heavy chain

n.
Either of the two larger polypeptide chains in an immunoglobulin molecule, consisting of a variable region that contains the antigen-binding portion and a constant region that is specific to each immunoglobulin class or subclass.

heavy chain

n
(Medicine) immunol a type of polypeptide chain present in an immunoglobulin molecule
References in periodicals archive ?
NMR [sup.1]H (DMSO) [delta](ppm): 1.56 (s, 6H, C[H.sub.3]); 3.35 (s, 3H, NC[H.sub.3]); 5.28 (d, J = 15.0 Hz, 1H, H-chain); 7.03 (t, J = 8.3 Hz, 1H, Ar-H); 7.13 (d, J = 9.0 Hz, 1H, Ar-H); 7.26 (t, J = 8.3 Hz, 1H, Ar-H); 7.43 (d, J = 7.7 Hz, 1H, Ar-H); 7.66 (d, J = 15.0 Hz, 1H, H-chain); 13.15 (s, 1H, NH).
NMR [sup.1]H (CD[Cl.sub.3]) [delta] (ppm): 1.29 (t, J = 6.0 Hz, 3H, C[H.sub.3] 1.66 (s, 6H, C[H.sub.3]); 3.32 (s, 3H, NC[H.sub.3]); 4.19 (q, J = 6.7 Hz, 2H, C[H.sub.2]); 5.17 (d, / = 16.5 Hz, 1H, H-chain); 6.86 (d, J = 6.7 Hz, 1H, Ar-H); 707 (t, / = 6.7 Hz, 1H, Ar-H); 7.24-7.28 (m, 2H, Ar-H); 7.91 (d, / = 16.5 Hz, 1H, H-chain).
The patient had anti-dsDNA antibodies (Kallestad Quantafluor Crithidia lucilae Sanofi Diagnostic Pasteur, Inc.) but positive anticardiolipin antibodies by enzyme-linked immunosorbent assay (ELISA) (100 GPL units) (negative test = [is less than]10 GPL units) (ImmunoWell, Cardiolipin Antibody Immunoglobulin [Ig]G ELISA; and Reaads Medical Products, Inc.), which remained positive 4 and 12 months later, and antiplatelet antibodies by immunofluorescence (AntiHuman IgG H-chain Fluorescein conjugated, OTIY-05 Behring Diagnostics).