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More than 9 million people in our country are living with HBV and 10 million with HCV.
The serological course of chronic HBV has greatly been debated.
Blood, Enzyme Linked Immuno Sorbent Assay (ELISA), HBsAg, PCR and HBV.
Moreover, phylogenetic analysis of HBV genome sequences helps understanding the epidemiology of this infection and the virus spread through a given geographical region.
Methods: We assessed 148 chronic HBV patients and 148 ageand gender-matched healthy controls by dual energy X-ray absorptiometry (DEXA) for determination of BMD.
For many patients, available therapies already provide a functional cure of HBV defined as viral loads below detection.
Conclusion: The frequency of HbeAg was found in a significant number of chronic HBV patients.
Following the Phase 1a study, a Phase 1b study will assess the safety, pharmacokinetics and preliminary antiviral efficacy of ABI-H0731 in patients with chronic HBV infection.
Occult HBV is the major contributor for transfusion transmitted HBV infection in highly endemic countries such as India.
Conclusion: Although pre induction screening of HBV infection is carried out in Pak Army still its prevalence is matched with that of general Pakistani population.
9,10,12) Though HBV is transmitted by percutaneous or mucosal exposure to infected blood or other body fluids, transfusion-associated HBV continues to be a major problem in India, especially among multiple transfused patients despite testing for HBsAg in blood donors.
Part B would be a single-dose study composed of up to 28 patients with chronic HBV infection.
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- HBV pre-S2 trans-regulated protein 3
- HBV PreS1-transactivated protein 2
- HBV X-associated protein 1
- HBV X-associated protein 2
- HBV X-transactivated gene 2 protein
- HBV XAg-transactivated protein 2
- HBV-X associated protein