Normal plasma concentration of Hcy
is ranged as 4-12 umol/l while mean Hcy
concentrations are 5.6 umol/l at 8-16 weeks, 4.3umol/l at 20-28 weeks, and 5.5umol/l at 36-42 weeks of gestation10,11.
Thus, the aim of this study was to determine the Hcy
levels in type 2 diabetics and correlate Hcy
with HbA1c levels, BMI, blood pressure and duration of diabetes.
Biochemical examination showed high plasma total Hcy
level (495 [micro]mol/L [normal <15 [micro]mol/L]).
From a biological viewpoint, Hcy
methylation is influenced by several rate-limiting enzymes, and thereof methylenetetrahydrofolate reductase (MTHFR) is a key enzyme.
Ophthalmologists required urgent surgery He was diagnosed with MTHFR deficiency during early babyhood, and his Hcy
level two months prior wasl81 [micro]mol [L.sup.-1] His pediatrician administered high doses of ASA (15 mg [kg.sup.-1]).
The inflammatory markers used were Hcy
, ultra-sensitive C-reactive protein (CRP), interleukin 6 (IL-6), TNF-[alpha], and serum ferritin.
Los alcoholicos cronicos normalmente tienen niveles elevados de Hcy
. En este contexto, se ha encontrado asociacion entre los niveles plasmaticos elevados de Hcy
y el consumo de alcohol, sosteniendo que el consumo de etanol incrementa los niveles de metilacion del ADN (Bonsch et al., 2004, 2006).
However, other studies showed that hyperinsulinemia can cause elevated plasma Hcy
by impairing the activity of Hcy
metabolizing enzymes [30,31].
is also metabolized to the thioester Hcy-thiolactone in an error-editing reaction in protein biosynthesis when Hcy
is erroneously selected in place of Met by methionyl-tRNA synthetase .
To evaluate the specificity of the assay, the spectral response of probe 1 towards various biologically relevant analytes including twenty natural protein amino acids, AA, Hcy
, and GSH was recorded.
Demographic information, smoking habit, history of hypertension, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), 24 h urinary albumin excretion and ACR, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglycerides (TG), and homocysteine (Hcy
) of each participant were obtained.
As the primary outcomes were changes in the concentrations of CRP, Hcy
, follistatin, TNF-[alpha], IL-6, leukocyte total number, and several adhesion molecules with the use of COCs, only studies in which individuals were used as their own control were included.