(3) The
HLA system is part of the major histocompatibility complex (MHC) that modulates the host immune response.
The
HLA system: genetics, immunology, clinical testing, and clinical implications.
Thus, Psoriasis can be classified into the
HLA system:
However, there is no complete list of alleles for each locus within the
HLA system [7] because there are an increasing number of HLA alleles identified as genotyping technique increase (Figure 2).
The antigens of the
HLA system are determined by genes present in the major histocompatibility complex which is located on the short arm at the 6th chromosome (6p21.3) in humans and extends over some 4 centimorgans of DNA, about 4 x[10.sup.6] base pair.
The idiosyncrasy of the
HLA system, therefore, has resulted in the development of standards by the American Society of Histocompatibility and Immunogenetics.
The complete, fully characterized sequence of each identified novel HLA gene, stretching from the 5' end of exon 1 through the 3' end of the last exon (exon 7 of HLA-B and exon 8 of HLA-A and HLA-C including all encompassed introns were submitted to GenBank and the WHO HLA Nomenclature Committee for factors of the
HLA system. The WHO Nomenclature Committee officially assigned every allele name in April of 2016 following the policy outlined in the most recent Nomenclature Report (26).
Sirona Genomics was spun out of the Stanford Genome Technology Center at Stanford University with a focus on developing next generation sequencing typing applications specifically for the
HLA System.
The
HLA system is comprised of polymorphic cell-surface proteins important for antigen presentation.
HLA-C and HLA-B are members of the
HLA system. DC-SIGN and SDF1 are related to chemokines.
Evidence for a role of the
HLA system in Dupuytren's disease suggests that the immune system plays a role in the disease.7