(3) The HLA system
is part of the major histocompatibility complex (MHC) that modulates the host immune response.
The HLA system
: genetics, immunology, clinical testing, and clinical implications.
Thus, Psoriasis can be classified into the HLA system
However, there is no complete list of alleles for each locus within the HLA system
 because there are an increasing number of HLA alleles identified as genotyping technique increase (Figure 2).
The antigens of the HLA system
are determined by genes present in the major histocompatibility complex which is located on the short arm at the 6th chromosome (6p21.3) in humans and extends over some 4 centimorgans of DNA, about 4 x[10.sup.6] base pair.
The idiosyncrasy of the HLA system
, therefore, has resulted in the development of standards by the American Society of Histocompatibility and Immunogenetics.
The complete, fully characterized sequence of each identified novel HLA gene, stretching from the 5' end of exon 1 through the 3' end of the last exon (exon 7 of HLA-B and exon 8 of HLA-A and HLA-C including all encompassed introns were submitted to GenBank and the WHO HLA Nomenclature Committee for factors of the HLA system
. The WHO Nomenclature Committee officially assigned every allele name in April of 2016 following the policy outlined in the most recent Nomenclature Report (26).
Sirona Genomics was spun out of the Stanford Genome Technology Center at Stanford University with a focus on developing next generation sequencing typing applications specifically for the HLA System
The HLA system
is comprised of polymorphic cell-surface proteins important for antigen presentation.
HLA-C and HLA-B are members of the HLA system
. DC-SIGN and SDF1 are related to chemokines.
Evidence for a role of the HLA system
in Dupuytren's disease suggests that the immune system plays a role in the disease.7