HLA system


Also found in: Medical.
Related to HLA system: human leukocyte antigen

HLA system

n
(Biochemistry) human leucocyte antigen system; a group of the most important antigens responsible for tissue compatibility, together with the genes that encode them. For tissue and organ transplantation to be successful there needs to be a minimum number of HLA differences between the donor's and recipient's tissue
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
References in periodicals archive ?
(3) The HLA system is part of the major histocompatibility complex (MHC) that modulates the host immune response.
The HLA system: genetics, immunology, clinical testing, and clinical implications.
Thus, Psoriasis can be classified into the HLA system:
However, there is no complete list of alleles for each locus within the HLA system [7] because there are an increasing number of HLA alleles identified as genotyping technique increase (Figure 2).
The antigens of the HLA system are determined by genes present in the major histocompatibility complex which is located on the short arm at the 6th chromosome (6p21.3) in humans and extends over some 4 centimorgans of DNA, about 4 x[10.sup.6] base pair.
The idiosyncrasy of the HLA system, therefore, has resulted in the development of standards by the American Society of Histocompatibility and Immunogenetics.
The complete, fully characterized sequence of each identified novel HLA gene, stretching from the 5' end of exon 1 through the 3' end of the last exon (exon 7 of HLA-B and exon 8 of HLA-A and HLA-C including all encompassed introns were submitted to GenBank and the WHO HLA Nomenclature Committee for factors of the HLA system. The WHO Nomenclature Committee officially assigned every allele name in April of 2016 following the policy outlined in the most recent Nomenclature Report (26).
Sirona Genomics was spun out of the Stanford Genome Technology Center at Stanford University with a focus on developing next generation sequencing typing applications specifically for the HLA System.
The HLA system is comprised of polymorphic cell-surface proteins important for antigen presentation.
HLA-C and HLA-B are members of the HLA system. DC-SIGN and SDF1 are related to chemokines.
Evidence for a role of the HLA system in Dupuytren's disease suggests that the immune system plays a role in the disease.7