human leukocyte antigen

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human leukocyte antigen

n. Abbr. HLA
Any of various cell-surface antigens in humans that are products of the major histocompatibility complex and are used to type tissue, as to match donors with recipients for organ transplantation.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

HLA

human leukocyte antigen: any of a complex of genetically determined antigens, occurring on the surface of almost every human cell, by which one person's cells can be distinguished from another's and histocompatibility established.
[1970–75]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
References in periodicals archive ?
In brief, by having a detailed list of unacceptable and acceptable donor antigens (based on the recipient's HLA antibody profile) and the high-resolution HLA type of potential donors, an electronic crossmatch (paper crossmatch or crossmatch in silico) can be performed, perhaps one day obviating the need for a physical crossmatch.
In addition, Affymetrix Axiom HLA Analysis software enables affordable, high-throughput, accurate analysis of 11 classical loci at 4-digit resolution by imputing HLA type from Axiom array-generated genotype data.
The three peaks shown in the electropherogram resulted from the cells of the most recent stem cell donor, the father, (HLA type DPB1*04:01, 17:01) and from the patient, including the leukemic cells (HLA type DPB1*04:01, 04:01).
(6) This technique is a solid-phase assay in which purified HLA molecules (either of a single HLA type or a combination of types) are attached to beads.
The HLA type for the patient R.Z., by the LABTYPE SSO Typing test (Luminex one Lambda Inc technology), showed these results: HLA A 01, A 29, B 18, B 51, DQB1 01, DQB1 05 , DRB1 11, DRB1 15 ...
A bone marrow donor's HLA type must be a pretty exact match with a particular patient's HLA type in order for transplantation to proceed.
Allogeneic bone marrow transplantations today require that the patient and donor immune systems (HLA type) are highly similar in order to reduce the risk of GvHD and therefore rely on matching donors.
The less specific HLA type DR4 is seen in 82%-96% of patients with actinic prurigo and in 30%-40% of people who do not have the disorder.
To find someone's HLA type is to determine which alleles she has at specific locations on the chromosome.
Further testing may indicate that your precise HLA type is compatible with the patient.