human leukocyte antigen

(redirected from HLA type)
Also found in: Medical, Encyclopedia.

human leukocyte antigen

n. Abbr. HLA
Any of various cell-surface antigens in humans that are products of the major histocompatibility complex and are used to type tissue, as to match donors with recipients for organ transplantation.

HLA

human leukocyte antigen: any of a complex of genetically determined antigens, occurring on the surface of almost every human cell, by which one person's cells can be distinguished from another's and histocompatibility established.
[1970–75]
References in periodicals archive ?
The results show that TPIV200 vaccination was well tolerated by all patients and over 90% developed robust and durable antigen-specific immune responses against FRa without regard for HLA type, which aligns with the intended mechanism of action of the vaccine.
For hla antibody detection, For obtaining reagents or reagent kits for hla type determination (sbt method), Dna amplification, Gel electrophoresis, Capillary electrophoresis, And rna isolation.
In brief, by having a detailed list of unacceptable and acceptable donor antigens (based on the recipient's HLA antibody profile) and the high-resolution HLA type of potential donors, an electronic crossmatch (paper crossmatch or crossmatch in silico) can be performed, perhaps one day obviating the need for a physical crossmatch.
In addition, Affymetrix Axiom HLA Analysis software enables affordable, high-throughput, accurate analysis of 11 classical loci at 4-digit resolution by imputing HLA type from Axiom array-generated genotype data.
If a recipient has antibodies against a donor's HLA type, the antibodies will bind to the donor's cells and the crossmatch should be positive, whereas if the recipient does not have antiHLA donor-specific antibodies, the crossmatch should be negative.
The HLA type of our patient (DRB 15) was similar to the familial polish study (5) Environment agents are probably incriminated in the pathogenesis of sarcoidosis in our patients.
A bone marrow donor's HLA type must be a pretty exact match with a particular patient's HLA type in order for transplantation to proceed.
The less specific HLA type DR4 is seen in 82%-96% of patients with actinic prurigo and in 30%-40% of people who do not have the disorder.
To find someone's HLA type is to determine which alleles she has at specific locations on the chromosome.
Further testing may indicate that your precise HLA type is compatible with the patient.
Because a medical test can determine the HLA type of a person in just an hour, physicians may someday routinely use HLA type to decide how aggressively to treat a person with strep A infection.