HMG-CoA reductase


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Related to HMG-CoA reductase: Mevalonate
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Noun1.HMG-CoA reductase - a liver enzyme that is responsible for producing cholesterol
reductase - an enzyme that catalyses the biochemical reduction of some specified substance
References in periodicals archive ?
Approved in strengths of 1 mg, 2 mg and 4 mg, Zypitamag is an HMG-CoA reductase inhibitor indicated for patients with primary hyperlipidemia or mixed dyslipidemia as an adjunctive therapy to diet to reduce elevated total cholesterol, low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), triglycerides, and to increase high-density lipoprotein cholesterol (HDL-C).
ZYPITAMAG, which is approved in strengths of 1 mg, 2 mg and 4 mg, is an HMG-CoA reductase inhibitor indicated for Patients with primary hyperlipidemia or mixed dyslipidemia as an adjunctive therapy to diet to reduce elevated total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), triglycerides (TG) as well as to increase high-density lipoprotein cholesterol (HDL-C), according to the company.
Researchers from Sriwijaya University in Indonesia tested the effects of various peptides filtered out of bekasam, a fermented fish paste used in Indonesian cooking, on the enzyme HMG-CoA reductase.
Statins, also known as HMG-CoA reductase inhibitors are competitive inhibitor of the rate-limiting enzyme, 3-hydroxy 3-methylglutaryl coenzyme-A (HMG-CoA) reductase in cholesterol synthesis.
The liver was analyzed for HMG-CoA reductase concentration and hepatic lipase activity whiles cholesterol, LDL and HDL concentrations were measured in the blood serum.
Like statin drugs, monacolins inhibit cholesterol synthesis by inhibiting HMG-CoA reductase and also decrease C-reactive protein levels.
Statins are drugs that block a cholesterol-producing enzyme in the liver called HMG-CoA reductase.
Statins might help prevent CRC through HMG-CoA reductase inhibition and other mechanisms, according to the researchers.
Therefore, statin is referred to HMG-CoA reductase inhibitors.
HMG-CoA reductase catalyzes the reduction of HMG-CoA to mevalonate, which is the rate-limiting step in cholesterol synthesis in the liver.
Activity of plasma lipoprotein lipase (LPL), HMG-CoA reductase and lecithin cholesterol acyltransferase (LCAT) were assayed by the method of Korn 1955, Philipp and Shapiro (1970) and Hitz et al.