The supplemental indication is for treating hypercholesterolemia patients who are not suitable for HMG-CoA reductase
inhibitor ("statin") therapy.
Bempedoic acid is a first-in-class oral inhibitor of ATP citrate lyase, an enzyme that is inactive in skeletal muscle--thus, the lack of myalgia complaints--and lies upstream of HMG-CoA reductase
in cholesterol synthesis.
Specifically, statins may have the ability to lower blood cholesterol by reducing its capacity to synthesize in the liver by inhibition of HMG-CoA reductase
. In more recent years, pharmacotherapy using natural therapy has been used to limit the different unwanted side effects.
The authors propose that curcumin may have multiple mechanisms of action that make it beneficial for treatment of NAFLD, including its ability to decrease expression of HMG-CoA reductase
, and to decrease lipogenesis and adipogenesis.
Statins inhibit HMG-CoA reductase
, which converts HMG-CoA to mevalonate., In cancerous cells and noncancerous cells, statins have been reported to inhibition of the mevalonate pathway and induction of ER stress.,,,, Inconsistent with these studies, our study has demonstrated that simvastatin treatment significantly inhibited ER stress in the ox-LDL-treated EC.
ZYPITAMAG, which is approved in strengths of 1 mg, 2 mg and 4 mg, is an HMG-CoA reductase
inhibitor indicated for Patients with primary hyperlipidemia or mixed dyslipidemia as an adjunctive therapy to diet to reduce elevated total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), triglycerides (TG) as well as to increase high-density lipoprotein cholesterol (HDL-C), according to the company.
Lipid-lowering agents act by inhibiting HMG-CoA reductase
, thus reducing cholesterol biosynthesis.
It also has a short-elimination half-life, is cleared through both hepatic and renal routes, and is among the most hepatoselective statins available (one of the weakest inhibitors of HMG-CoA reductase
kit was procured from Beijing Chenglin Biotechnology Ltd., China.
Researchers from Sriwijaya University in Indonesia tested the effects of various peptides filtered out of bekasam, a fermented fish paste used in Indonesian cooking, on the enzyme HMG-CoA reductase
. They found two peptides inhibited the enzyme.
Statins, also known as HMG-CoA reductase
inhibitors are competitive inhibitor of the rate-limiting enzyme, 3-hydroxy 3-methylglutaryl coenzyme-A (HMG-CoA) reductase in cholesterol synthesis.