Reynaud and collaborators, including first author and post-doctoral research fellow Jung-Mi Lee, show that obesity related stresses alter the cellular architecture of the hematopoietic stem cell
compartment and reduce its long-term functional fitness.
Oxidative stresses in the body caused by obesity drive overexpression of Gfi1, producing a lasting alteration of the hematopoietic stem cell
By administering a pharmacological agent, the matching molecular scissors called "Cre" can be activated in the animals' hematopoietic stem cells
The report provides comprehensive information on the therapeutics under development for Hematopoietic Stem Cell
Transplantation, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type.
This report provides comprehensive information on the therapeutic development for Hematopoietic Stem Cell
Transplantation, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases.
Plerixafor acts as an antagonist of the alpha chemokine receptor CXCR4, a procedure which is significant in hematopoietic stem cell
homing to the bone marrow, doctors said.
A snapshot of the global therapeutic scenario for Hematopoietic Stem Cell
ProHema is produced through a two-hour, ex vivo modulation process, which significantly activates key biological pathways involved in hematopoietic stem cell
homing, proliferation and survival in pre-clinical models.
Scientists can make red and white blood cells from embryonic stem cells easily in the laboratory, but producing blood stem cells, called hematopoietic stem cells
, has been much more difficult, Zon says.
Recent studies of Helicobacter infection in mice have suggested that bone marrow hematopoietic stem cells
can contribute to repopulating the gastric mucosal epithelium.
Nontuberculous mycobacterial infection in hematopoietic stem cell
and solid organ transplant recipients.
They noted that autologous hematopoietic stem cell
transplantation can be considered for select patients at experienced institutions with severe myasthenia gravis for whom the risks of this procedure are outweighed by its potential benefits.