heparan sulfate

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hep·a·ran sulfate

A glycosaminoglycan found on cell surfaces and basement membranes in mammals that regulates a wide variety of biological processes, including angiogenesis and blood coagulation. Also called heparitin sulfate.

[hepar(in) (to which it is close in structure) + -an.]
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References in periodicals archive ?
Antibodies have also been generated against the substrate that accumulates in LSD patients (Table 1), including heparan sulfate (48), keratan sulfate (49), [G.
The objectives of this study were to evaluate the integrity of the blood-brain barrier and structural brain abnormalities in MPS IIIB patients using multimodal magnetic resonance imaging (MRI), cerebrospinal fluid CSF-albumin index (CSF-AI), and measuring heparan sulfate (HS) levels in the cerebrospinal fluid (CSF), blood, and urine.
Armand began his career at the University of Chicago in the early 1960's where he was involved in the isolation and structural characterization of heparan sulfate and dermatan sulfate from skin fibroblasts and from urine derived from patients with "Hurler Syndrome ", a form of mucopolysaccharidoses.
Kolm V, Sauer U, Olegomoller B, Scheicher ED (1996) High-glucose-induced TGF-[beta]1 regulates mesangial production of heparan sulfate proteoglycan.
will be showcasing the company's newly launched dermatological product, Sente Dermal Repair Cream, which features a proprietary formulation of the active ingredient heparan sulfate (HS).
Syndecans are cell-surface transmembrane heparan sulfate proteoglycans with a variety of functions in the cell.
Ji ZS, Dichek HL, Miranda RD, Mahley RW (1997) Heparan sulfate proteoglycans participate in hepatic lipase and apolipoprotein E-mediated binding and uptake of plasma lipoproteins, including high density lipoproteins.
Sente Dermal Repair Cream features a proprietary formulation of the active ingredient heparan sulfate (HS).
An extra modification step occurs in heparin and heparan sulfate by the deacetylation and N-sulfation of GlcNAc residues.
MPS 7 is caused by the deficiency of beta-glucuronidase, an enzyme required for the breakdown of the glycosaminoglycans (GAGs) dermatan sulfate and heparan sulfate.
MPS II is caused by accumulation of the glycosaminoglycans heparan sulfate and dermatan sulfate, which occurs as a result of a deficiency of the lysosomal enzyme iduronate-2-sulfatase (IDS; EC 3.
MPS 7 is an extremely rare autosomal recessive lysosomal storage disorder characterized by a deficiency of the lysosomal enzyme Beta-glucuronidase, required for the degradation of the glycosaminoglycans dermatan sulfate (DS) and heparan sulfate (HS).