Kawasaki et al., "Intrahepatic huge hematoma due to rupture of small hepatocellular adenoma
: a case report," Hepatology Research, vol.
There are difficulties in histological identification, such as cirrhosis with hepatocellular adenoma
and well-differentiated HCC. Early HCC is seen as a carcinoma in situ , displaying high proliferation and differentiation, and its differential diagnosis from dysplastic nodules mainly depends on a series of morphological characteristics, which are often hard to identify, especially in biopsy specimens.
Glypican-3.--Glypican-3 (GPC3) is an oncofetal protein that can be detected in 70% to 80% of HCCs but not in benign hepatocellular lesions, such as hepatocellular adenoma
. (112-114) Positive stains can be cytoplasmic, membranous, canalicular, and/or cytoplasmic dotlike.
Management of focal nodular hyperplasia and hepatocellular adenoma
in young women: a series of 41 patients with clinical, radiological, and pathological correlations.
Neither HBcAg nor HBx were expressed in stem cells present within tumor or adjacent nontumor tissues from an HBV negative patient with HCC and another HBV negative patient with hepatocellular adenoma
(data not shown).
16 cases of isolated caudate lobectomy were performed for neoplasms confined to the caudate lobe, including seven cases of hepatocellular carcinoma (7/16, 43.75%), four cases of hepatic cavernous hemangioma (4/16, 25%), one case of hepatocellular adenoma
(1/16, 6.25%), one case of inflammatory pseudotumor (1/16,6.25%), one case of hepatic hamartoma (1/16, 6.25%), one case of mixed hepatocellular carcinoma and cholangiocellular carcinoma (1/16, 6.25%), and one case of metastatic colonic cancer (1/16, 6.25%).
Vascular problems-including hepatic artery aneurysm, portal vein thrombosis, and hematoma as well as neoplastic processes such as hemangioma, hepatocellular adenoma
and carcinoma, infantile hemangioendothelioma, cholangiocarcinoma, hepatoblastoma, and metastatic tumors of the liver represent the remaining etiologies.
The distinction between well-differentiated hepatocellular carcinoma and hepatocellular adenoma
is also difficult .
is a rare, benign liver neoplasm which is usually found in young women.
(3,5,6) Apart from renal tract anomalies, associated congenital abnormalities are typically more common in Type 1 CEPS.3,5 Nodular liver lesions are also seen, including regenerative nodular hyperplasia, focal nodular hyperplasia and hepatocellular adenoma
, which are benign, but hepatoblastoma and hepatocellular carcinoma has also been reported.
(9, 11) Use of GPC-3 has also been advocated for distinguishing well-differentiated HCC from hepatocellular adenoma
. (25-27) Based on our results, the utility of GPC-3 in this setting is limited because it is positive in only 62% (8 of 13) of well-differentiated HCC.
Genotype-phenotype correlation in hepatocellular adenoma
: new classification and relationship with HCC.