Particularly naringenin and hesperetin
are the most important and common aglycones in the foods.
Antioxidative effects of hesperetin
against lead acetate-induced oxidative stress in rats.
Quantification was performed by external standardization, using standard curves of epicatechin, daidzin, naringin, rutin, myricetin, hesperidin, diosmin, quercetin, genistein, naringinin, hesperetin
and kaempferol, flavonoids commonly reported in vegetables.
induced G1-phase cell cycle arrest in human breast cancer MCF-7 cells: involvement of CDK4 and p21.
Hesperidin(C28H32O15) is also called as hesperetin-7-rutinoside, or hesperetin
7-rhamnoglucoside and (S)-7-[[6-0-(6-deoxy-alpha-L-mannop-yranosyl)-beta-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one (Fig.
Neuroprotective effects of chronic hesperetin
administration in mice.
(8) With phytochemical studies, D-sorbitol, apigenin, naringenin, eriodictoyl, vitexin, vitexin-4'-O-rhamnoside, hesperetin
, luteolin, luteolin 7-O-glucoside, quercetin, and hyperoside have been isolated from C.
While in vivo the exact mode of action of flavonoids is unclear, oxygraphic results for quercetin and hesperetin
support the shared working mechanism of both compounds by which they can increase exercise performance (Dorta et al., 2005).
The major bioflavonoids found in citrus fruits are diosmin, diosmetin, hesperidin, hesperetin
, naringin, naringenin, narirutin, neohesperidin, nobiletin, tangeretin, eriodictyol, and eriocitrin.
stimulated AMPK activation in a concentration- and time-dependent manner.
For example, hesperetin
aglycone (the active form of the flavonoid hesperidin) is metabolized by the cytochrome isoforms P450 CYP1A and CYP1B1.
has also shown to have a preventive effect against DR .