The literature review shows that study of reactions of ninhydrin is a subject of more interest and some of the useful reactions such as amidoalkylation, Knoevenagel condensation , oxidation [7,8], reduction [9,10], reaction with enols and aromatic compounds , synthesis of heterocyclic compounds
, Friedel-Crafts type reaction [13-16], Kolbe-Schmitt , Passerini , Wittig  and Morita-Baylis-Hillman  have been investigated in this area.
9,796,741, entitled "Aryl, Heteroaryl, and Heterocyclic Compounds
for Treatment of Complement Mediated Disorders," has been granted with claims to compositions of matter for ACH-4471 and additional compounds that inhibit complement factor D activity, a key mediator in the complement alternative pathway (AP).
In addition, thiazolidinones and their derivative products have a momentous position in the area of heterocyclic compounds
based on their presence in the structures of macrocyclic complex medications.
At the same time, Bulgariaas top import items from India include heterocyclic compounds
with nitrogen hetero-atom(s) only (17,4% of the total import) and raw tobacco (5.
These reactions can be used for the synthesis of heterocyclic compounds
About one hundred and ninety volatile compounds were detected using GC-MS which includes aldehydes ketones esters alcohols hydrocarbons ethers nitrogen oxygen sulfur phenols free acids heterocyclic compounds
Benzo[cicinnoline and its derivatives are important heterocyclic compounds
with antirheumatoid, as well as antimitotic properties.
Exports of Heterocyclic Compounds
with Nitrogen Hetero-Atom(S) Only has grew month on month basis by 7.
Such compounds includes aliphatic hydrocarbons, aldehydes, alcohols, ketones, esters, carboxylic acids, some aromatic hydrocarbons (Figure 1), and oxygenated heterocyclic compounds
such as lactones and alkylfurans (Mottram, 1998).
They then introduce experimental procedures for establishing the structure of metabolites using isotopes and physical methods, and detail the biochemical reactions involved in the biodegradation of major aliphatic, carbocyclic aromatic, and heterocyclic compounds
The steady growth in interest in heterocyclic compounds
is basically connected with their raised biological activity and also with the fact that they enable the development of novel materials with unique properties.
Oximes of six-membered heterocyclic compounds
with two and three heteroatoms: II.