This transcription factor with a heterodimeric
structure comprised an oxygen-regulated a subunit (HIF-[alpha]), and a constitutively expressed [beta] subunit (Semenza 2000) is translocated to the nucleus during hypoxia, where it binds to specific DNA sequences to regulate a large number of genes implicated in energetic metabolism, including 6-phosphofructo-2-kinase, fructose-2,6-biphosphatase 3 and 4, and COX subunits 4-1 (Minchenko et al.
14] Superantigens are proteins which have the ability to bind to HLA-DR molecules and specific V[beta] segments of heterodimeric
T-lymphocyte receptors and stimulate specific T-lymphocytes that express the Vb product.
ApoJ (also known as clusterin, CLU, SGP-2, SP-40, and gp80), a highly conserved heterodimeric
glycoprotein, has been observed to participate in a number of biological processes, such as lipid transportation, cell adhesion, complement-mediated cell lysis, and programmed cell death.
SSRP1 is a subunit of the faciliates chromatin transcription complex; it forms a heterodimeric
complex with SPT16 to regulate transcriptional elongation and possibly modulate DNA replication [17-19].
Interleukin (IL)-27, which consists of Epstein-Barr virus-induced gene 3 (EBI3, IL-12 p40-related protein) and IL-12 p35-related polypeptide p28, is a heterodimeric
cytokine belonging to IL-12/1L-23 family (13, 14).
Subsequently, DOF transcription factors display a complex modular structure by forming homo and heterodimeric
complexes, involve in multiple controlling processes, by acting as transcriptional activator or repressor of target genes (Yamamoto et al.
CDC7 is one of two heterodimeric
kinases involved in the cell cycle regulation of eukaryotic DNA replication.
Equine chorionic gonadotropin belongs to the class of heterodimeric
(a and [beta] subunits) glycoproteins.
Monomeric, dimeric, or heterodimeric
TLRs all signal through a tollinterleukin-1 receptor domain, ending up with the activation of the MyD88 adapter protein ; MyD88 then recruits the kinases associated to IL-1 receptor, eventually joining the NF-kB final common pathway.
Highly efficient generation of heritable zebrafish gene mutations using homoand heterodimeric
Similarly, Gly I, a heterodimeric
protein with 56 kDa, from Brassica juncea, is activated by calcium/calmodulin ([Ca.
However, SDS-PAGE revealed the presence of at least two bands with molecular masses between 70 and 100 kDa, which suggested that the SEPEC cytotoxic factor is a heterodimeric
protein complex with a molecular mass of ~150 kDa (Fig.