Goi, "Isoenzyme pattern and partial characterization of hexosaminidases in the membrane and cytosol of human erythrocytes," Clinical Biochemistry, vol.
Plasma membrane and cytosol glycohydrolases, namely, Hexosaminidase (HEX), [beta]-D-Glucuronidase (GCR), [alpha]-D-Glucosidase ([alpha]-GLU), and O-[beta]-N-Acetyl-glucosaminidase (O-GlcNAcase,), were also found in human erythrocytes where [9,10] they have a role in signalling early membrane alterations , in pathologies related to strong oxidative stress, such as type 2 diabetes mellitus  or Down's syndrome [12, 13].
Mammal lysosomal [beta]-N-acetyl-D hexosaminidases are mainly responsible for glycoconjugate degradation in lysosome.
Most of the higher eukaryotes contain two or more genes for the hexosaminidases. For example, Arabidopsis thaliana contains Hex1, Hex2, and Hex3 .