hexosaminidase

(redirected from Hexosaminidases)
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hexosaminidase

(ˌhɛksəʊsəˈmɪnɪˌdeɪz; ˌhɛksəʊsəˈmɪnɪˌdeɪs)
n
(Biochemistry) the enzymes that catalyse the metabolism of gangliosides
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References in periodicals archive ?
Goi, "Isoenzyme pattern and partial characterization of hexosaminidases in the membrane and cytosol of human erythrocytes," Clinical Biochemistry, vol.
Plasma membrane and cytosol glycohydrolases, namely, Hexosaminidase (HEX), [beta]-D-Glucuronidase (GCR), [alpha]-D-Glucosidase ([alpha]-GLU), and O-[beta]-N-Acetyl-glucosaminidase (O-GlcNAcase,), were also found in human erythrocytes where [9,10] they have a role in signalling early membrane alterations [6], in pathologies related to strong oxidative stress, such as type 2 diabetes mellitus [11] or Down's syndrome [12, 13].
Mammal lysosomal [beta]-N-acetyl-D hexosaminidases are mainly responsible for glycoconjugate degradation in lysosome.
Most of the higher eukaryotes contain two or more genes for the hexosaminidases. For example, Arabidopsis thaliana contains Hex1, Hex2, and Hex3 [11].
Thermal fractionation of serum hexosaminidases: applications to heterozygote detection and diagnosis of Tay-Sachs disease.
A glycine250 to aspartate substitution in the [alpha]-subunit of hexosaminidase A causes juvenile-onset Tay-Sachs disease in a Lebanese-Canadian Family.
Isolation and relationship of human hexosaminidases. J Biol Chem 1974; 249:3488-99.
Juvenile GM2 gangliosidosis (AMB variant): inability to activate hexosaminidase A by activator protein.
Expression of hexosaminidase isoenzymes in childhood leukemia.