There are records of Hr molecules involved in other functions besides oxygen loading, such as in the storage of iron atoms, detoxification of heavy metals, and innate immunity pathways of some species of annelids (e.g., Theromyzon tessulatum, Hirudo
medicinalis, and Neanthes diversicolor; Baert et al., 1992; Demuynck et al., 1993; Vergote et aL, 2004; reviewed by Coates and Decker, 2017).
Biopharm breeds Hirudo
verbana and Hirudo
medicinalis, both known as medicinal leeches.
Penile replantation using the leech Hirudo
Torre, "Spontaneous electrical activity and behavior in the leech Hirudo
medicinalis," Frontiers in Integrative Neuroscience, vol.
Medicinalis, the medical leeches working through sucking the congested replanted finger as well as inducing bleeding through secretion of hirudin which was first extracted in 1957 by Markwardt and a protease inhibitor found in Hirudo
medicinalis salivary glands, is a potent inhibitor of thrombin .
Only one, Hirudo
medicinalis, has been (and still is) in medical use.
This 64-aar peptide, which is produced in the salivary glands of the medical leech Hirudo
medicinalis, possesses an extremely high inhibiting capacity ([K.sub.i] = [10.sup.-14]) and specificity towards thrombin (29).
It is a product consisting of eight ingredients including Radix Ginseng Rubra , Herba Epimedii Brevicornus , Fructus Psoraleae , Fructus Lycii , Herba Ephedrae Sinicae , Asarum Heterotropoides , Radix Salviae Miltiorrhizae , and Hirudo
But by collecting them, workers caused the number of our only bloodsucking leeches, Hirudo
medicinalis, to plunge by 1900.
Rinaldi et al., "The multifunctional role of fibroblasts during wound healing in Hirudo
medicinalis (Annelida, Hirudinea)," Biology of the Cell, vol.
The effects of feeding regime on the growth and reproduction of the medicinal leech Hirudo
The material is extracted from Hirudo
leeches and also contains Pheretima (defined below).