Effect of the chronic ingestion of chlorimipramine and desipramine on the hole board
response to acute stresses in male rats.
The modified hole board
as a differential screen for behavior in rodents.
Therefore the present study was designed to evaluate and to find out the central importance of oxytocin in combating the most common male psychological disorders anxiety, fear, stress and exploratory behavior by using well established hole board test, elevated plus maze, open field test in preclinical models.
10 min after the intracerebroventricular administration of saline / oxytocin the observations was recorded for hole board, elevated plus maze and open-field test for 5 min .
Hole Board Test in male wistar rats and swiss albino mice
Hole board test used to assess number of pokings in the holes by animals during 5 min time.
administered saline/oxytocin on Behavior of male swiss albino mice in hole board
test Treatment Total number % Decrease in of pokings number of pokings Normal 11.
This notion is further supported by the observation that BTB induced anxiolytic action was not accompanied by muscle relaxation (as evident by bar test), motor incoordination (as judged by Bridge and righting reflex tests), sedation (as reflected from hole board
test) or promotion of sleep (as judged by absence of ptosis, sleepiness and unimpairment of autogrooming), which are common side effects of benzodiazepenes (Rang 1995).
Exploratory behavior and curiosity were measured using a hole board apparatus and placing non-trained mice on the board and recording the number of holes explored in a 5 minute period.
This was confirmed through a more specific test which uses a hole board apparatus and where an evident reduction of the exploratory and curiosity activity of mice was observed.