The use of human artificial chromosomes overcomes both of these problems by providing a new chromosome in addition to the ones that already exist in the cells of the subject.
A new generation of human artificial chromosomes for functional genomics and gene therapy.
She asserted that human artificial chromosomes
are sometimes known as 'chromosome 47' as the normal complement of chromosomes in human cells is 46, explaining that the advantage in gene therapy is that the 47th chromosome doesn't interfere with the other 46 chromosomes, unlike conventional gene therapy where an extra gene is inserted often at random into the human genome.
* Geneticists assembled the first human artificial chromosomes
Ignorance of the structure, and even the size, of human centromeres has been the fundamental reason that scientists hadn't been able to create human artificial chromosomes