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A rare genetic disorder of childhood that is characterized by rapid onset of the physical changes typical of old age, usually resulting in death before the age of 20. Also called Hutchinson-Gilford progeria syndrome.

[pro- + Greek gēras, old age; see geriatrics + -ia.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Pathology) med premature old age, a rare condition occurring in children and characterized by small stature, absent or greying hair, wrinkled skin, and other signs of old age
[C20: from pro-2 + Greek gēras old age]
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(proʊˈdʒɪər i ə)

a rare congenital abnormality characterized by premature and rapid aging, the affected individual appearing in childhood as an aged person.
[1900–05; < Greek progḗr(ōs) prematurely old (pro- pro-2 + -gēros, adj. derivative of gêras old age) + -ia]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.progeria - a rare abnormality marked by premature aging (grey hair and wrinkled skin and stooped posture) in a child
abnormalcy, abnormality - an abnormal physical condition resulting from defective genes or developmental deficiencies
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.


n progeria
English-Spanish/Spanish-English Medical Dictionary Copyright © 2006 by The McGraw-Hill Companies, Inc. All rights reserved.
References in periodicals archive ?
He heads the laboratory of regenerative medicine at the Clinical Research Center for Pediatric Hematology, Oncology and Immunology where his research interests include Hutchinson-Gilford Syndrome, new methods of cellular reprogramming, molecular mechanisms of skin and cartilage regeneration and personalized medicine in oncology.
Progeria (also known as "Hutchinson-Gilford progeria syndrome" and "Hutchinson-Gilford syndrome"1) is a rare and severe genetic condition in which symptoms of aging are manifested at an early age.
This PA is a new initiative to support research to understand how mutations in the gene for lamin A/C affect nuclear structure, thus leading to bothdysfunction of the nuclear envelope, and depending on the mutation, Hutchinson-Gilford syndrome in humans (Eriksson et al., manuscript in preparation).

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