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 (hī′ə-lo͝o-rŏn′ĭ-dās′, -dāz′)
An enzyme that catalyzes the breakdown of hyaluronic acid in the body, thereby increasing tissue permeability to fluids. Also called spreading factor.


(ˌhaɪəlʊˈrɒnɪˌdeɪs; -ˌdeɪz)
(Biochemistry) an enzyme that breaks down hyaluronic acid, thus decreasing the viscosity of the medium containing the acid
[C20: hyalo- + Greek ouron urine + -id3 + -ase]


(ˌhaɪ ə lʊˈrɒn ɪˌdeɪs, -ˌdeɪz)

an enzyme that decreases viscosity in the tissue spaces of the body by breaking down hyaluronic acid: used as an ingredient for diffusing injected drugs.
[1935–40; hyaluron(ic acid) + -id- + -ase]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.hyaluronidase - an enzyme (trade name Hyazyme) that splits hyaluronic acid and so lowers its viscosity and increases the permeability of connective tissue and the absorption of fluids
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
References in periodicals archive ?
The AR combination also up-regulated genes associated with formation of extracellular matrix including heparan sulfate proteoglycan 2 (HSPG2) and hyaluronoglucosaminidase 1 (FIYAL1).
Up-regulated genes included heparan sulfate proteoglycan 2 (HSPG2), hyaluronoglucosaminidase 1 (HYAL1) and interleukin 7 (IL-7), and down-regulated genes included interleukin 6 (1L-6), and C-reactive protein (CRP), as well as cathepsin G (CTSG), tachykinin receptor 1 (TACR1), chemokine (C-X3-C motif) ligand 1(CX3CL1), frizzled homolog 1 (FZD1), and insulin-like growth factor 2 (IGF2).
In a previous study on buffalo semen, egg yolk-citrate glucose, egg yolk tris, skim milk-egg yolk and citric acid whey conserved NAR with similar efficiency but minimum release of hyaluronoglucosaminidase was observed in skim milk egg yolk extender when cooled to 5C (Kakar and Anand, 1984).