hybridoma

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hy·brid·o·ma

 (hī′brĭ-dō′mə)
n.
A cell that is produced in the laboratory by fusing an antibody-producing lymphocyte (which does not readily divide) with a nonantibody-producing cancer cell (which divides rapidly). The hybridoma proliferates and produces a continuous supply of a specific monoclonal antibody.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

hybridoma

(ˌhaɪbrəˈdəʊmə)
n
(Biochemistry) a hybrid cell formed by the fusion of two different types of cell, esp one capable of producing antibodies, but of limited lifespan, fused with an immortal tumour cell
[C20: from hybrid + -oma]
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

hy•brid•o•ma

(ˌhaɪ brɪˈdoʊ mə)

n., pl. -mas.
a hybrid cell made in the laboratory by fusing a normal cell with a cancer cell, usu. a myeloma or lymphoma, in order to combine desired features of each, as the ability of the cancer cell to multiply rapidly with the ability of the normal cell to dictate the production of a specific antibody.
[1975–80]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.hybridoma - a hybrid cell resulting from the fusion of a lymphocyte and a tumor cell; used to culture a specific monoclonal antibody
somatic cell, vegetative cell - any of the cells of a plant or animal except the reproductive cells; a cell that does not participate in the production of gametes; "somatic cells are produced from preexisting cells";
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
Translations
hybridome

hy·brid·o·ma

n. hibridoma, célula somática híbrida capaz de producir anticuerpos.
English-Spanish Medical Dictionary © Farlex 2012
References in periodicals archive ?
It is suitable for growing antibody-secreting cell lines, including hybridomas and Chinese hamster ovary (CHO) cells.
AutovaxID is suitable for growing antibody-secreting cell lines, including hybridomas and Chinese hamster ovary (CHO) cells which are currently the back bone of commercial therapeutic protein manufacture.
The technology includes monoclonal antibodies and related hybridomas and other related know-how.
Because individual hybridomas are cultured, crude preparations can be used to elicit immune responses, but the cell lines that demonstrate affinity to the immunogen must be screened for specificity post-culture.
It will cover research applications, technology, and methods in a wide array of topic areas, including recombinant DNA, gene cloning and sequencing; DNA structure and metabolism; RNA structure, metabolism, and expression; genetic engineering; gene therapy; transgenics (plant and animal); antisense research and technology; monoclonal antibodies and hybridomas; drug discovery and development; protein structure, function, and engineering; PCR in research and application; and apoptosis/ programmed cell death.
However, from the time the first gene was cloned successfully in 1973, attention has focused on the "new" generation of biotechnology, encompassing the techniques of genetic engineering, hybridomas and biochemical engineering.
The result: new, hybrid tumor cells, or hybridomas. In the laboratory flasks, these hardworking hybridomas become tiny factories, churning out antibodies.
hybridomas), while multicellular organisms or "higher life forms" are living organisms having more than one cell and which include plants, animals, and humans.
In 2003, two murine hybridomas, clones 3C2 and 38G6, secreting specific monoclonal antibodies (MAb) to allergens derived from the American cockroach, Periplaneta americana, were produced in our laboratory (Sookrung et al.
Hybridomas were selected in hypoxanthineaminopterin-thymidine medium and maintained in vitro by methods modified from Van Deusen (1983) in Dulbecco's modified Eagle's medium supplemented with 15% horse serum (Sigma).
The reactivity of the antibodies produced by the hybridomas was then determined.