hypermutable

(redirected from Hypermutation)
Also found in: Medical.

hypermutable

(ˌhaɪpəˈmjuːtəbəl)
adj
(Medicine) med characterized by a rapid occurrence of mutation
References in periodicals archive ?
AnaptysBio's antibody pipeline has been developed using its proprietary somatic hypermutation, or SHM platform, which uses in vitro SHM for antibody discovery and is designed to replicate key features of the human immune system to overcome the limitations of competing antibody discovery technologies.
AnaptysBio Announces Second Quarter 2019 Financial Results and Provides Pipeline Updates
In mature B-cell neoplasms, characteristic translocations involving the immunoglobulin loci originate from aberrant V(D)J recombination, class switch recombination, or activation-induced cytidine deaminase-mediated somatic hypermutation. Although most of the breakpoints in the immunoglobulin loci occur at defined positions, those in the partner genes can occur anywhere over large areas of extragenic, nontranscribed sequences.
Molecular Fingerprinting of Anatomically and Temporally Distinct B-Cell Lymphoma Samples by Next-Generation Sequencing to Establish Clonal Relatedness
Inactivation of MMR protein function is well known to have numerous biological consequences, including genome instability, resistance to DNA damaging agents including chemotherapeutic drugs, [18] altered class switch recombination and somatic hypermutation of immunoglobulin genes, [19] emergence of pathogenic bacteria, infertility, promotes TNR expansion [20,21] and increased susceptibility to cancer.
OVERVIEW OF MISMATCH REPAIR PATHWAY
We use a neighborhood operator called hypermutation, inspired from [24].
Multiobjective Optimization for Multimode Transportation Problems
Han et al., "Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells," Nature Methods, vol.
Protein Engineering Strategies to Expand CRISPR-Cas9 Applications
Nones et al., "Hypermutation in pancreatic cancer," Gastroenterology, vol.
A Contemporary Review of the Treatment Landscape and the Role of Predictive and Prognostic Biomarkers in Pancreatic Adenocarcinoma
Zuhlke-Jenisch et al., "Chromosomal translocations fusing the BCL6 gene to different partner loci are recurrent in primary central nervous system lymphoma and may be associated with aberrant somatic hypermutation or defective class switch recombination," Journal of Neuropathology & Experimental Neurology, vol.
Case Reports in Oncological Medicine Myoepithelioma: A New Rearrangement Involving the LPP Locus in a Case of Multiple Bone and Soft Tissue Lesions
The algorithm comprises five immune operators: cloning operator, hypermutation operator, suppression operator, selection and receptor editing operator, and memory updating operator, and one genetic operator: crossover operator.
Multiobjective Simulation-Based Optimization Based on Artificial Immune Systems for a Distribution Center
Thus, B cells undergo somatic hypermutation and immunoglobulin class-switching recombination as a part of the GC reactions mediated by the activation-induced cytidine deaminase (AID) enzyme [92].
Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases
Gould, "Local somatic hypermutation and class switch recombination in the nasal mucosa of allergic rhinitis patients," The Journal of Immunology, vol.
Microbiota Composition and the Integration of Exogenous and Endogenous Signals in Reactive Nasal Inflammation
The clones then undergo somatic hypermutation and produce antibodies that are specific to the invading antigen.
A Novel Immune-Inspired Shellcode Detection Algorithm Based on Hyperellipsoid Detectors
Dictionary browser ?
Full browser ?