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A cartilage cell located in a lacuna of the cartilage matrix.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
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The recent literature suggests that Sema3A is expressed by prehypertrophic and hypertrophic chondrocytes during endochondral ossification which precedes neurovascular invasion [21].
In the proximity of the diaphysis the hypertrophic chondrocytes (CH) enter into apoptosis, left an ECM scaffold for the bone tissue in formation (van der Eerden et al.).
Classic metaphyseal lesions are believed to consist of hypertrophic chondrocytes which results from lack of blood supply due to injury and no subsequent resorption of terminal chondrocytes [20,21].
Notably, there were no apparent increases in the presence of hypertrophic chondrocytes with large and round shapes in the IGF-1 transduced pellets as compared with the control pellets (Figure 3(b) upper lane).
MMP-9 (gelatinase B), similar to MMP-1, is most active during embryonic development, being essential to angiogenesis in the growth plate and apoptosis of hypertrophic chondrocytes in utero [16].

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