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Related to IL-8: Il-6, TNF alpha


Any of various small proteins that are produced by a variety of cell types, especially T cells and other white blood cells, and that regulate many aspects of inflammation and the immune response, including stimulating the production of white blood cells and platelets.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Biochemistry) a substance extracted from white blood cells that stimulates their activity against infection and may be used to combat some forms of cancer
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˈɪn tərˌlu kɪn)
any of a family of small proteins that participate in the body's defense system, esp. by promoting the growth and activation of white blood cells.
[1979; inter- + leuk (ocyte) + -in1; so called because such proteins act as agents of communication between different populations of leukocytes]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.interleukin - any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system
lymphokine - a cytokine secreted by helper T cells in response to stimulation by antigens and that acts on other cells of the immune system (as by activating macrophages)
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
o IL-1?, IL-1?, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-13, IL-15, IL-17, IL-23, IFN-?, TNF-?, TNF-?
After 24 h of treatment, we collected the PBMCs and the supernatants and then determined the protein or mRNA levels of cytokines, including IL-1[sz], IL-33, IL-6, IL-8, and tumor necrosis factor-a (TNF-a).
Silencing of endogenous IL-32 in differentiated THP-1 human macrophages significantly decreased TNF-[alpha], IL-1[beta], and IL-8 production and simultaneously increased the M.
To further elucidate the pathogenesis of IRIS, we analyzed gene expression changes of NFAT1-NFAT4 and the major target genes IL-2, IL-6, IL-8, TNF-[alpha], IL-1[beta], IL-10, and IL-12 in peripheral blood [CD3.sup.+] T cells before and during the course of IRIS.
IL-6, TNF, IL-8 monoclonal antibodies, standard samples, and negative controls were provided by Professor Jin Boquan from the Department of Immunological Teaching and Research of the Fourth Military University.
A no primary antibody, B no treatment, C, IL-15 (100ng/ml); D, IL-8 (100ng/ml); E, IL-1b/TNF-a (100ng/ml).
A simple method for determining cell-associated IL-8 was described by Marie et al.
In addition, keratinocytes in psoriasis as well as synoviocytes in RA are capable of responding to direct IL-36 ligands stimulation with production of IL-6, IL-8, and antimicrobial peptides, which cooperate with IL-17A and TNF-alpha promoting neutrophil activation and migration [11, 54, 56, 60].
The potential roles of cytokines, IL-5 and IL-8, and plasma cortisol in the anti-inflammatory actions of phosphodiesterase inhibitors in sensitized guinea-pig airways.
Interleukin-8 (IL-8) is a cytokine produced by a variety of cells in response to stimuli, such as bacterial lipopolysaccharide, with a strong chemotactic activity on neutrophils.